ArticleCritical care (London, England)2019
The early change of SOFA score as a prognostic marker of 28-day sepsis mortality: analysis through a derivation and a validation cohort.
Article in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 77 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clarithromycin as Immunomodulatory Therapy for the Management of Septic Syndrome by Ventilator-Associated Pneumonia
A Double-blind Randomized Placebo-controlled Clinical Trial of the Safety and Efficacy of Intravenous Clarithromycin as Immunomodulatory Therapy for the Management of Sepsis
Evaluation of Presepsin and Syndecan-1 as Biomarkers for Early Diagnosis and Prognosis of Sepsis Following Major Surgeries
Efficacy and Safety of Sodium-Glucose Cotransporter 2 Inhibitors in Adults With Sepsis: A Feasibility Study for a Multicenter Double-Blind Randomized Placebo-Controlled Trial
Who cites it
77 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prediction models for mortality in patients with sepsis: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Using Body Composition Analysis for Improved Nutritional Intervention in Septic Patients: A Prospective Interventional Study.Nutrients · 2023Trial
- Evaluate prognostic accuracy of SOFA component score for mortality among adults with sepsis by machine learning method.BMC infectious diseases · 2023Trial
- Establishment of a prognostic model for patients with sepsis based on SOFA: a retrospective cohort study.The Journal of international medical research · 2021Trial
- Day-7 lactate-to-albumin ratio as a prognostic marker in sepsis patients requiring prolonged mechanical ventilation: a multicenter retrospective landmark analysis of the Korean Sepsis Alliance registry.Journal of thoracic disease · 2026Article
- Different longitudinal patterns of sequential organ failure assessment (SOFA) and SOFA-2 scores during extracorporeal membrane oxygenation and continuous renal replacement therapy in septic cardiomyopathy.Journal of anesthesia · 2026Article
- Longitudinal dynamics of gut microbiota and mycobiota in pneumonia-derived sepsis: evidence of taxonomic stability and trans-kingdom network reorganization.Gut pathogens · 2026Article
- The new SOFA for sepsis identification and mortality prediction: a multicenter cohort study.Journal of intensive care · 2026Article
- Establishing a nomogram of the risk of in-hospital mortality in children with suspected sepsis and validating the applicability of the Phoenix.BMC pediatrics · 2026Article
- Monocyte Distribution Width and Composite Biomarker Assessment for Prognostic Stratification of Sepsis in the Intensive Care Unit.Biomedicines · 2026Article
- Serial assessment of serum HMGB1 and ΔSOFA for predicting 28-day mortality in sepsis patients: a prospective cohort study in the emergency department.BMC emergency medicine · 2026Article
- Granulocyte and monocyte adsorption therapy in sepsis: a propensity score-matched analysis.Journal of intensive care · 2026Article
- Prognostic Value of the Albumin-to-Prealbumin Ratio in Elderly Patients with Sepsis.Journal of clinical medicine · 2026Article
- Development and external validation of a 90-day mortality prediction model for comatose sepsis patients: impact of cerebrovascular disease and dementia.Frontiers in medicine · 2026Article
- Elevated growth differentiation factor-15 in sepsis: clinical associations and immune cell context.Frontiers in cell and developmental biology · 2026Article
- Identification of Monocyte CD11c as a Potential Biomarker for Distinguishing Sepsis From Non-Infectious Inflammation and Predicting the Outcome of Sepsis.Journal of inflammation research · 2026Article
- Temporal phenotyping and prognostic stratification of patients with sepsis through longitudinal clustering.BioData mining · 2025Article
- Development and validation of a prediction model for in-hospital mortality in patients with sepsis.Nursing in critical care · 2025Article
- Granulocyte and Monocyte Adsorption Therapy in Patients With Sepsis: A Feasibility Study.Artificial organs · 2025Article
- Clinical implement of Probe-Capture Metagenomics in sepsis patients: A multicentre and prospective study.Clinical and translational medicine · 2025Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSince the Sepsis-3 criteria, change in Sequential Organ Failure Assessment (SOFA) score has become a key component of sepsis identification. Thus, it could be argued that reversal of this change (Δ
methodsData from two previously published randomized controlled trials were studied: the first reporting on patients with severe Gram-negative infections as a derivation cohort and the second reporting on patients with ventilator-associated pneumonia as a validation cohort. Only patients with sepsis according to the Sepsis-3 definition were included in this analysis. SOFA scores were calculated on days 1, 2, 3, 5, 7, 14, and 28.
resultsWe included 448 patients within the derivation cohort and 199 within the validation cohort. Mean SOFA scores on day 1 were 6.06 ± 4.07 and 7.84 ± 3.39, and 28 day mortality 22.8% and 29.6%, respectively. In the derivation cohort, the earliest time point where Δ
conclusionsΔ
trial registrationClinicalTrials.gov numbers NCT01223690 and NCT00297674.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.