Evidence map›Paper›PMID 31783874›Full record

ArticleJournal of orthopaedic surgery and research2019

The serum level of D-Dimer is not suitable for distinguishing between prosthetic joint infection and aseptic loosening.

Jincheng Huang, Yongchao Zhang, Zhen Wang, Yonghui Dong, Yongqiang Zhao, Jia Zheng, Hongkai Lian, Yi Jin

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 8 pooled it
10.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 8 syntheses or guidelines pooled it, 63 citations in OpenAlex.

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  17. Utility of D-dimer in total joint arthroplasty.World journal of orthopedics · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Jincheng HuangDepartment of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China.
Yongchao ZhangDepartment of Orthopedics, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, 450007, China.
Zhen WangDepartment of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China.
Yonghui DongDepartment of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China.
Yongqiang ZhaoDepartment of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China.
Jia ZhengDepartment of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China. zhengjiaguke@163.com.
Hongkai LianDepartment of Orthopedics, Zhengzhou Central Hospital, Zhengzhou University, Zhengzhou, 450007, China. lianhongkaidavid@163.com.
Yi JinDepartment of Orthopedics, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Zhengzhou, 450003, China. 397923402@qq.com.
Henan Provincial People's Hospital · CNZhengzhou Central Hospital · CNZhengzhou University · CNHenan University · CN

Funding

Doctoral Scientific Research Foundation of Henan Provincial People's Hospital Huang Jincheng2018Ministry of Science and Technology National Key Research and Development Program of China 2017YFB1104100
6 · The paper itself

Abstract

backgroundTo evaluate the meaning of serum CRP, ESR, and D-Dimer in the diagnosis of prosthetic joint infection.

methodsIn a retrospective study, 101 patients presented with osteoarthritis, PJI, and aseptic loosening were divided into three groups according to the type of operation they received in our department from June 2016 to December 2018: group A, 44 patients treated with primary arthroplasty; group B, 31 PJI patients treated with resection arthroplasty and spacer insertion surgery; group C, 26 aseptic loosening patients treated with revision arthroplasty. Data such as gender, age, preoperative serum CRP, ESR, and D-Dimer level were compared among the three different groups.

resultsThere are no statistically significant differences when comparing general data such as gender and age in patients from the three different groups. However, Serum CRP level in group B (43.49 ± 10.00 mg/L) is significantly higher than in group A (2.97 ± 0.75 mg/L) and C (4.80 ± 1.26 mg/L). Serum ESR level in group B (49.84 ± 5.48 μg/L) is significantly higher than those in group A (15.28 ± 2.63 μg/L) and C (22.50 ± 3.47 μg/L). Serum D-Dimer level in group B (1.58 ± 0.17 μg/L) is significantly higher than that in group A (0.51 ± 0.50 μg/L), but similar with group C (1.22 ± 0.29 μg/L). There are no statistically significant differences when compared with sensitivity and specificity of CRP, ESR, and D-Dimer in the diagnosis of PJI among patients from the three different groups when D-Dimer > 0.85 μg/L was set as the optimal threshold value for the diagnosis of PJI.

conclusionD-Dimer is not a parameter to distinguish between aseptic loosening and PJI.

Indexed as

Prosthesis FailureAgedArthritis, InfectiousBlood SedimentationC-Reactive ProteinDiagnosis, DifferentialFemaleFibrin Fibrinogen Degradation ProductsHumansMaleMiddle AgedProsthesis-Related InfectionsRetrospective StudiesC-Reactive ProteinFibrin Fibrinogen Degradation Productsfibrin fragment DCRPD-DimerDiagnosisESRProsthetic joint infection

Identifiers

PMID31783874
PMCPMC6884846
OpenAlexW2990199158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.