ArticleJournal of orthopaedic surgery and research2019
Risk factors of neurological deficit and pulmonary cement embolism after percutaneous vertebroplasty.
Article in Journal of orthopaedic surgery and research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 51 citations in OpenAlex.
- A Nomogram to Predict Intra-Spinal Canal Cement Leakage Among Elderly Patients with Spine Metastases: An Internal-Validated Model.Clinical interventions in aging · 2021Trial
- Safety and efficacy of decompressed vertebroplasty in reducing pulmonary fat embolism: a proof-of-mechanism study in a sheep model.North American Spine Society journal · 2026Article
- Cement leakage and post-operative outcomes after lower-versus higher-volume bone cement injection in percutaneous vertebroplasty: a systematic review and meta-analysis of randomized controlled trials.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Risk factors for bone cement leakage in percutaneous vertebroplasty and its prevention.Pakistan journal of medical sciences · 2026Article
- Asymptomatic Multiple Bilateral Segmental Pulmonary Embolisms Caused by Cement After Multilevel Vertebroplasty: A Case Report and Literature Review.Case reports in surgery · 2026Article
- Risk factors associated with bone cement leakage following percutaneous kyphoplasty: a retrospective analysis.European journal of medical research · 2025Article
- Biomechanical insights into anterolateral vertebral screw fixation in osteoporotic spines: a comparative study of fixation methods and positions using porcine vertebrae.Journal of orthopaedic surgery and research · 2025Article
- Warning line for preventing bone cement leakage in surgery involving percutaneous kyphoplasty for osteoporotic vertebral compression fractures.Frontiers in surgery · 2025Article
- Recent Advances in Minimally Invasive Management of Osteolytic Periacetabular Skeletal Metastases.Seminars in interventional radiology · 2024Review
- Construction and clinical validation of risk model for predicting bone cement leakage after the surgical management of spinal metastases.American journal of cancer research · 2024Article
- Development of patient-tailored preoperative assessment of percutaneous vertebroplasty.Frontiers in surgery · 2024Article
- An Incidental Finding of Pulmonary Cement Embolism Four Weeks After Vertebroplasty in a 50-Year-Old Man with Multiple Myeloma.The American journal of case reports · 2023Article
- Complications of Percutaneous Vertebroplasty: A Pictorial Review.Medicina (Kaunas, Lithuania) · 2023Review
- Impact of Aspiration Percutaneous Vertebroplasty in Reducing Bone Cement Leakage and Enhancing Distribution-An Ex Vivo Study in Goat Vertebrae.Bioengineering (Basel, Switzerland) · 2023Article
- The significance of the best puncture side bone cement/vertebral volume ratio to prevent paravertebral vein leakage of bone cement during vertebroplasty: a retrospective study.BMC musculoskeletal disorders · 2023Article
- Article
- CT features and risk factors of pulmonary cement embolism after vertebroplasty or kyphoplasty in patients with vertebral compression fracture: a retrospective cohort study.Quantitative imaging in medicine and surgery · 2023Article
- Risk factors for pulmonary cement embolism after percutaneous vertebroplasty and radiofrequency ablation for spinal metastases.Frontiers in oncology · 2023Article
- Case report: Shock after percutaneous vertebroplasty of the 5th thoracic vertebra.Frontiers in surgery · 2023Article
- Advances in materials used for minimally invasive treatment of vertebral compression fractures.Frontiers in bioengineering and biotechnology · 2023Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe risk factors, incidence, and clinical management of pulmonary cement embolism and neurological deficit during percutaneous vertebroplasty (PVP) were evaluated.
methodsThree thousand one hundred and seventy-five patients with symptomatic osteoporotic vertebral compression fractures (OVCFs) treated with PVP were retrospectively reviewed in a single institution. Clinical parameters such as age, gender, number of fractures, and time from fracture to vertebroplasty were recorded at the time of surgery. Image and surgical parameters including the amount of cement, the vertebral level, uni- or bipedicle surgical approach, and leakage pattern were recorded.
resultsType-C leakage, including paraspinal (25%), intradiscal (26%), and posterior (0.7%) leakage, was more common than type-B (11.4%) and type-S leaks (4.9%). Cement leakage into the spinal canal (type-C posterior) occurred in 26 patients (0.7%), and four patients needed surgical decompression. Three in nine patients with leakage into thoracic spine needed decompressive surgery, but only one of 17 patients into lumbar spine needed surgery (p < 0.01). Age, gender, number of fractures, and time from fracture to vertebroplasty were not risk factors of pulmonary cement embolism or neurological deficit. The risk factor of pulmonary cement embolism was higher volume of PMMA injected (p < 0.001) and risk factor of neurological deficit was type-C posterior cement leakage into thoracic spine. The incidence of pulmonary cement embolism was significantly high in the volume of PMMA injected (PMMA injection < 3.5 cc: 0%; 3.5-7.0 cc: 0.11%; > 7.0 cc: 0.9%; p < 0.01) which needed postoperative oxygen support.
conclusionsCement leakage is relatively common but mostly of no clinical significance. Percutaneous vertebroplasty in thoracic spine and high amount of PMMA injected should be treated with caution in clinical practice.
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