ArticleBMC plant biology2019
Comparative metabolomic analysis reveals the variations in taxoids and flavonoids among three Taxus species.
Article in BMC plant biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 30 citations in OpenAlex.
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- Fungal endophytes of Taxus species and regulatory effect of two strains on taxol synthesis.BMC microbiology · 2024Article
- Research on the Medicinal Chemistry and Pharmacology ofInternational journal of molecular sciences · 2024Review
- Metabolomics analysis of different diameter classes of Taxus chinensis reveals that the resource allocation is related to carbon and nitrogen metabolism.BMC plant biology · 2024Article
- Effect of fermentation on the constituents in the branches and leaves ofFrontiers in pharmacology · 2024Article
- Untargeted metabolomics inFrontiers in plant science · 2024Article
- Insights into Taxol® biosynthesis by endophytic fungi.Applied microbiology and biotechnology · 2023Review
- Exploring the Interplay between Metabolic Pathways and Taxane Production in ElicitedPlants (Basel, Switzerland) · 2023Article
- Analysis of the utilization value of different tissues of Taxus×Media based on metabolomics and antioxidant activity.BMC plant biology · 2023Article
- Flavonoid Components, Distribution, and Biological Activities inMolecules (Basel, Switzerland) · 2023Review
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- Natural Taxanes: From Plant Composition to Human Pharmacology and Toxicity.International journal of molecular sciences · 2022Review
- Role of female-predominant MYB39-bHLH13 complex in sexually dimorphic accumulation of taxol inHorticulture research · 2022Article
- Metabolomics study of flavonoids inPeerJ · 2022Article
- Investigation of bioactivities ofOpen life sciences · 2021Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundTrees of the genus Taxus are highly valuable medicinal plants with multiple pharmacological effects on various cancer treatments. Paclitaxel from Taxus trees is an efficient and widely used anticancer drug, however, the accumulation of taxoids and other active ingredients can vary greatly among Taxus species. In our study, the metabolomes of three Taxus species have been investigated.
resultsA total of 2246 metabolites assigned to various primary and secondary metabolic pathways were identified using an untargeted approach. Analysis of differentially accumulated metabolites identified 358 T. media-, 220 T. cuspidata-, and 169 T. mairei-specific accumulated metabolites, respectively. By searching the metabolite pool, 7 MEP pathway precursors, 11 intermediates, side chain products and derivatives of paclitaxel, and paclitaxel itself were detected. Most precursors, initiated intermediates were highly accumulated in T. mairei, and most intermediate products approaching the end point of taxol biosynthesis pathway were primarily accumulated in T. cuspidata and T. media. Our data suggested that there were higher-efficiency pathways to paclitaxel in T. cuspidata and T. media compared with in T. mairei. As an important class of active ingredients in Taxus trees, a majority of flavonoids were predominantly accumulated in T. mairei rather than T. media and T. cuspidata. The variations in several selected taxoids and flavonoids were confirmed using a targeted approach.
conclusionsSystematic correlativity analysis identifies a number of metabolites associated with paclitaxel biosynthesis, suggesting a potential negative correlation between flavonoid metabolism and taxoid accumulation. Investigation of the variations in taxoids and other active ingredients will provide us with a deeper understanding of the interspecific differential accumulation of taxoids and an opportunity to accelerate the highest-yielding species breeding and resource utilization.
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