Evidence map›Paper›PMID 31783739›Full record

Trial reportBMC pregnancy and childbirth2019

Effect of prenatal EPA and DHA on maternal and cord blood insulin sensitivity: a secondary analysis of the mothers, omega 3, and mental health study.

Joey A England, Joses Jain, Bradley D Holbrook, Ronald Schrader, Clifford Qualls, Ellen Mozurkewich

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC pregnancy and childbirth, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00711971 (Does EPA or DHA Prevent Depressive Symptoms in Pregnancy and Postpartum?), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00711971 phase2 / phase3completednot on this map

Does EPA or DHA Prevent Depressive Symptoms in Pregnancy and Postpartum?

TypeinterventionalSponsorUniversity of MichiganRan2008 to 2013Enrolled126ConditionsDepressionArmsEPA-rich fish oil supplement, DHA-rich fish oil supplement, placebo
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Does fetal leptin and adiponectin influence children's lung function and risk of wheeze?Journal of developmental origins of health and disease · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joey A EnglandDepartment of Obstetrics, Gynecology and Reproductive Sciences, McGovern Medical School, University of Texas Health Science Center at Houston, 6431 Fannin, MSB 3.286, Houston, 77030, USA. joey.a.england@uth.tmc.edu.ORCID http://orcid.org/0000-0001-6292-3220
Joses JainDepartment of Obstetrics and Gynecology, University of New Mexico, 915 Camino de Salud NE, MSC10-5580, Albuquerque, 87131, USA.
Bradley D HolbrookDepartment of Obstetrics and Gynecology, University of New Mexico, 915 Camino de Salud NE, MSC10-5580, Albuquerque, 87131, USA.
Ronald SchraderClinical and Translational Center, University of New Mexico, 915 Camino de Salud NE, MSC08-4635, Albuquerque, NM, 87131, USA.
Clifford QuallsClinical and Translational Center, University of New Mexico, 915 Camino de Salud NE, MSC08-4635, Albuquerque, NM, 87131, USA.
Ellen MozurkewichDepartment of Obstetrics and Gynecology, University of New Mexico, 915 Camino de Salud NE, MSC10-5580, Albuquerque, 87131, USA.
University of New Mexico · USThe University of Texas Health Science Center · US

Funding

University of New Mexico Clinical and Translational Science CenterUL1TR000041 · NCATS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI LARSON, RICHARD S · 2012 to 2014
$9.8M
Does EPA or DHA prevent depressive symptoms in pregnancy and postpartum?R21AT004166 · NCCIH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MOZURKEWICH, ELLEN · 2008 to 2011
$648k
National Center for Complementary and Alternative Medicine R21 AT004166-03S1NCATS NIH HHS 8UL1TR000041NCATS NIH HHS UL1 TR000041NCCIH NIH HHS R21 AT004166
6 · The paper itself

Abstract

backgroundWe sought to determine whether prenatal supplementation with the omega-3 fatty acids eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) would increase markers of insulin sensitivity in maternal or cord blood compared with placebo supplementation. A secondary aim was to evaluate the association of serum EPA and DHA fractions with adiponectin, leptin and the adiponectin:leptin ratio (ALR). We hypothesized that omega-3 fatty acid supplementation would increase markers of insulin sensitivity in maternal and umbilical cord plasma.

methodsWe analyzed stored plasma samples collected from a prior 3-arm prospective, double-blinded, randomized controlled trial in which 126 women with singleton pregnancies between 12- and 20-weeks' gestation were randomized to receive: 1) an EPA-rich fish oil supplement, 2) a DHA-rich fish oil supplement, or 3) a soy oil placebo. Maternal venous blood samples were collected at 12-20 weeks gestation (before supplementation) and at 34-36 weeks gestation. At delivery, cord blood was collected. Samples were analyzed using sandwich enzyme-linked immunosorbent assay kits to quantify leptin and adiponectin levels which were utilized to calculate the ALR, a proxy measure for insulin sensitivity.

resultsWe found no difference in adiponectin, leptin, and the ALR between the treatment and placebo groups at baseline, after supplementation, or in umbilical cord blood. In regression analyses, higher maternal serum DHA fraction was associated with increased ALR before (p = 0.01) and after (p = 0.04) DHA supplementation. There was no association of EPA fraction with any measure of insulin sensitivity. Cord blood DHA fraction was significantly associated with cord plasma leptin (p = 0.02). Early pregnancy BMI was significantly associated with maternal leptin levels at baseline and in late pregnancy (p < 0.001) and was inversely associated with the ALR (p < 0.001). The ALR decreased significantly between the early and late pregnancy visits (p < 0.001). Pregnancy weight gain was inversely associated with the ALR (P. < 0.02).

conclusionsEPA- and DHA- rich fish oil supplementation had no effect on plasma markers of insulin sensitivity. However, maternal serum DHA fraction was significantly associated with markers of insulin sensitivity.

trial registrationhttps://clinicaltrials.gov/, registration number NCT00711971, 7/7/2008.

Indexed as

Dietary SupplementsInsulin ResistancePrenatal CareAdiponectinAdultDocosahexaenoic AcidsDouble-Blind MethodEicosapentaenoic AcidFemaleFetal BloodHumansLeptinPregnancyProspective StudiesYoung AdultAdiponectinDocosahexaenoic AcidsEicosapentaenoic AcidLeptinDHAEPAInsulin sensitivityOmega-3 fatty acids

Identifiers

PMID31783739
PMCPMC6883625
OpenAlexW2989630537

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.