ArticleAntibiotics (Basel, Switzerland)2019
Increases in Hydrophilicity and Charge on the Polar Face of Alyteserin 1c Helix Change its Selectivity towards Gram-Positive Bacteria.
Article in Antibiotics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 52 citations in OpenAlex.
- Silver Sulfobenzoate Coordination Polymers as Bioactive Dopants in Antibacterial and Antibiofilm Cellulose Films.ACS applied materials & interfaces · 2026Article
- Bifunctional Peptides Generated by Optimising the Antimicrobial Activity of a Novel Trypsin-Inhibitory Peptide fromBiomolecules · 2026Article
- Pse-T2-Based Short Peptides with Broad-Spectrum Antimicrobial Activity, Stability, and Safety Combat MDRACS infectious diseases · 2025Article
- Design, Structural Stability, Membrane Binding, and Antibacterial Activity of Novel Antimicrobial Peptides Derived from Wuchuanin-A1.Life (Basel, Switzerland) · 2025Article
- Bioinspired Nanoplatforms: Polydopamine and Exosomes for Targeted Antimicrobial Therapy.Polymers · 2025Review
- Synthesis of Cyclic Hexapeptides via the Hydrazide Method and Evaluation of Their Antibacterial Activities.Molecules (Basel, Switzerland) · 2025Article
- Understanding the selectivityFrontiers in bioinformatics · 2025Article
- Article
- Characterization and Classification In Silico of Peptides with Dual Activity (Antimicrobial and Wound Healing).International journal of molecular sciences · 2023Article
- Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Effect of radiation sterilisation on the structure and antibacterial properties of antimicrobial peptides.Biomaterials translational · 2023Article
- Functional Characterization, Antimicrobial Effects, and Potential Antibacterial Mechanisms ofMarine drugs · 2022Article
- Integrating In Vitro and In Silico Analysis of a Cationic Antimicrobial Peptide Interaction with Model Membranes of Colistin-ResistantPharmaceutics · 2022Article
- How to Combat Gram-Negative Bacteria Using Antimicrobial Peptides: A Challenge or an Unattainable Goal?Antibiotics (Basel, Switzerland) · 2021Review
- Key Physicochemical Determinants in the Antimicrobial Peptide RiLK1 Promote Amphipathic Structures.International journal of molecular sciences · 2021Article
- A Study of the Interaction of a New Benzimidazole Schiff Base with Synthetic and Simulated Membrane Models of Bacterial and Mammalian Membranes.Membranes · 2021Article
- Plant antimicrobial peptides: structures, functions, and applications.Botanical studies · 2021Review
- In Silico Selection and Evaluation of Pugnins with Antibacterial and Anticancer Activity Using Skin Transcriptome of Treefrog (Pharmaceutics · 2021Article
- Antimicrobial Contribution of Chitosan Surface-Modified Nanoliposomes Combined with Colistin against Sensitive and Colistin-Resistant ClinicalPharmaceutics · 2020Article
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Recently, resistance of pathogens towards conventional antibiotics has increased, representing a threat to public health globally. As part of the fight against this, studies on alternative antibiotics such as antimicrobial peptides have been performed, and it has been shown that their sequence and structure are closely related to their antimicrobial activity. Against this background, we here evaluated the antibacterial activity of two peptides developed by solid-phase synthesis, Alyteserin 1c (WT) and its mutant derivative (ΔM), which shows increased net charge and reduced hydrophobicity. These structural characteristics were modified as a result of amino acid substitutions on the polar face of the WT helix. The minimum inhibitory concentration (MIC) of both peptides was obtained in Gram-positive and Gram-negative bacteria. The results showed that the rational substitutions of the amino acids increased the activity in Gram-positive bacteria, especially against
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.