Evidence map›Paper›PMID 31783620›Full record

ArticlePharmaceutics2019

A Non-Viral Plasmid DNA Delivery System Consisting on a Lysine-Derived Cationic Lipid Mixed with a Fusogenic Lipid.

María Martínez-Negro, Natalia Sánchez-Arribas, Andrés Guerrero-Martínez, María Luisa Moyá, Conchita Tros de Ilarduya, Francisco Mendicuti, Emilio Aicart, Elena Junquera

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Research Progress on Liposome Pulmonary Delivery ofJournal of aerosol medicine and pulmonary drug delivery · 2024
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Barriers and Strategies of Cationic Liposomes for Cancer Gene Therapy.Molecular therapy. Methods & clinical development · 2020
    Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

María Martínez-NegroDepartamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Natalia Sánchez-ArribasDepartamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-4236-1894
Andrés Guerrero-MartínezDepartamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0001-8576-2896
María Luisa MoyáGrupo de Química Coloidal y Catálisis Micelar, Departamento de Química Física, Facultad de Química, Universidad de Sevilla, 41012 Sevilla, Spain.ORCID 0000-0002-2736-9348
Conchita Tros de IlarduyaDepartamento de Tecnología y Química Farmacéuticas, Facultad de Farmacia y Nutrición, Universidad de Navarra, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31080 Pamplona, Spain.ORCID 0000-0001-6414-2719
Francisco MendicutiDepartmento de Química Analítica, Química Física e Ingeniería Química and Instituto de Investigación Quimica Andrés M. del Rio, Universidad de Alcalá, 28871 Alcalá de Henares, Spain.
Emilio AicartDepartamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0003-1654-4136
Elena JunqueraDepartamento de Química Física, Facultad de Ciencias Químicas, Universidad Complutense de Madrid, 28040 Madrid, Spain.ORCID 0000-0002-0655-5782
Universidad Complutense de Madrid · ESNavarre Institute of Health Research · ESUniversidad de Alcalá · ESUniversidad de Sevilla · ES

Funding

Ministerio de Economía, Industria y Competitividad, Gobierno de España CTQ2015-65972-R, CTQ2015-64425-C2-1-R, CTQ2015-64425-C2-2-R, CTQ2016-80600-P and RTI2018-095844-B-I00Universidad Complutense de Madrid UCMA05-33-010Universidad de Alcalá CCGP2017-EXP/027
6 · The paper itself

Abstract

The insertion of biocompatible amino acid moieties in non-viral gene nanocarriers is an attractive approach that has been recently gaining interest. In this work, a cationic lipid, consisting of a lysine-derived moiety linked to a C

Indexed as

compactiongene deliverylipoplexlysine-derived cationic lipidmolecular dynamicsmultilamellar aggregatesplasmid DNAprotectiontransfection

Identifiers

PMID31783620
PMCPMC6956073
OpenAlexW2990225688

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.