ArticleCancers2019
Delineation of Tumor Migration Paths by Using a Bayesian Biogeographic Approach.
Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed.
- The tree labeling polytope: A unified approach to ancestral reconstruction problems.Cell systems · 2026Article
- Bayesian inference of tissue-migration histories in metastatic cancer from cell-lineage tracing data.Cell genomics · 2026Article
- Resolving tumor evolution: a phylogenetic approach.Journal of the National Cancer Center · 2024Review
- Improving cellular phylogenies through the integrated use of mutation order and optimality principles.Computational and structural biotechnology journal · 2023Article
- Article
- Tumors Are Evolutionary Island-Like Ecosystems.Genome biology and evolution · 2021Article
- The somatic molecular evolution of cancer: Mutation, selection, and epistasis.Progress in biophysics and molecular biology · 2021Article
- Migrations of cancer cells through the lens of phylogenetic biogeography.Scientific reports · 2021Article
- PathFinder: Bayesian inference of clone migration histories in cancer.Bioinformatics (Oxford, England) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Understanding tumor progression and metastatic potential are important in cancer biology. Metastasis is the migration and colonization of clones in secondary tissues. Here, we posit that clone migration events between tumors resemble the dispersal of individuals between distinct geographic regions. This similarity makes Bayesian biogeographic analysis suitable for inferring cancer cell migration paths. We evaluated the accuracy of a Bayesian biogeography method (BBM) in inferring metastatic patterns and compared it with the accuracy of a parsimony-based approach (metastatic and clonal history integrative analysis, MACHINA) that has been specifically developed to infer clone migration patterns among tumors. We used computer-simulated datasets in which simple to complex migration patterns were modeled. BBM and MACHINA were effective in reliably reconstructing simple migration patterns from primary tumors to metastases. However, both of them exhibited a limited ability to accurately infer complex migration paths that involve the migration of clones from one metastatic tumor to another and from metastasis to the primary tumor. Therefore, advanced computational methods are still needed for the biologically realistic tracing of migration paths and to assess the relative preponderance of different types of seeding and reseeding events during cancer progression in patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.