ArticleHepatology research : the official journal of the Japan Society of Hepatology2020
Zinc deficiency in patients with chronic liver disease in Japan.
Article in Hepatology research : the official journal of the Japan Society of Hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- A randomized clinical study to evaluate the possible antifibrotic effect of zinc sulfate in chronic HCV patient receiving direct-acting anti-viral therapy.Inflammopharmacology · 2025Trial
- Pemafibrate therapy increases serum zinc levels in patients with metabolic dysfunction-associated steatohepatitis: a prospective study.BMC gastroenterology · 2026Article
- The predictive factors of hypozincemia in patients with chronic liver disease.Journal of nutritional science · 2026Article
- Risk factors, clinical outcomes, and the development of a pragmatic zinc deficiency screening tool in patients with cirrhosis: a prospective cohort study.European journal of clinical nutrition · 2026Article
- Correlation of Serum Zinc Levels with Hepatic Encephalopathy Severity in Patients with Decompensated Liver Cirrhosis: A Prospective Observational Study from Egypt.Biological trace element research · 2025Observational
- Serum zinc levels as predictors of covert hepatic encephalopathy in patients with liver cirrhosis.Journal of gastroenterology · 2025Observational
- Zinc Deficiency as a General Feature of Cancer: a Review of the Literature.Biological trace element research · 2024Review
- Pathophysiological-Based Nutritional Interventions in Cirrhotic Patients with Sarcopenic Obesity: A State-of-the-Art Narrative Review.Nutrients · 2024Review
- The Significance of Zinc in Patients with Chronic Liver Disease.Nutrients · 2022Review
- The Possible Effects of Zinc Supplementation on Postpartum Depression and Anemia.Medicina (Kaunas, Lithuania) · 2022Article
- The relationship between zinc deficiency and infectious complications in patients with hepatitis B virus-related acute-on-chronic liver failure.Gastroenterology report · 2022Article
- Hypozincemia in Chronic Hepatitis C Is Improved with Viral Clearance by Direct-acting Antiviral Agents.Internal medicine (Tokyo, Japan) · 2021Article
- Serum Zinc Level Is Associated with Frailty in Chronic Liver Diseases.Journal of clinical medicine · 2020Article
- Zinc deficiency in patients with chronic liver disease in Japan.Hepatology research : the official journal of the Japan Society of Hepatology · 2020Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to determine the distributions of serum zinc levels and the prevalence of zinc deficiency in patients with chronic liver disease (CLD) in actual clinical practice, and to analyze the association between serum zinc levels and clinical characteristics.
methodsThis study analyzed 1973 patients with CLD, including 749 with liver cirrhosis, who were admitted to Sapporo Kosei General Hospital in 2017.
resultsZinc deficiency, defined as a serum zinc level of <60 μg/dL, was observed in 555 patients overall (28.1%), including 182 (14.9%) patients without liver cirrhosis and 373 (49.8%) with liver cirrhosis. When marginal zinc deficiency was included, zinc deficiency (serum zinc level <80 μg/dL) was observed in 1594 (80.8%) patients overall, including 924 (75.5%) patients without liver cirrhosis and 670 (89.5%) with liver cirrhosis. Serum zinc levels were most strongly correlated with serum albumin levels. Of the 257 CLD patients with an albumin level of <3.5 g/dL, 234 (91.1%) had a serum zinc level of <60 μg/dL.
conclusionsZinc deficiency is common in patients with CLD. Serum zinc levels should be regularly measured, particularly in patients with liver cirrhosis.
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