Evidence map›Paper›PMID 31783247›Full record

ArticleAddictive behaviors2020

The number of biological parents with alcohol use disorder histories and risk to offspring through age 30.

Derek B Kosty, Richard F Farmer, John R Seeley, Kathleen R Merikangas, Daniel N Klein, Jeff M Gau, Susan C Duncan, Peter M Lewinsohn

Abstract read
In one paragraph

Article in Addictive behaviors, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Derek B KostyOregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA; University of Oregon, College of Education, 1585 E 13th Ave, Eugene, OR 97403, USA. Electronic address: dkosty@ori.org.
Richard F FarmerOregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA.
John R SeeleyOregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA; University of Oregon, College of Education, 1585 E 13th Ave, Eugene, OR 97403, USA.
Kathleen R MerikangasNational Institute of Mental Health, 35A Convent Drive, MSC #3720, Bethesda, MD 20892, USA.
Daniel N KleinStony Brook University, Psychology B Building, Stony Brook, NY 11794, USA.
Jeff M GauOregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA; University of Oregon, College of Education, 1585 E 13th Ave, Eugene, OR 97403, USA.
Susan C DuncanOregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA.
Peter M LewinsohnOregon Research Institute, 1776 Millrace Drive, Eugene, OR 97403, USA.

Funding

Family Study of Affective and Anxiety Spectrum DisordersZIAMH002804 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI MERIKANGAS, KATHLEEN R · 2009 to 2025
$37.5M
Family Transmission of Alcohol Use Disorder (AUD) RiskR01AA023842 · NIAAA · OREGON RESEARCH INSTITUTE · PI FARMER, RICHARD FRANCIS, SEELEY, JOHN R · 2016 to 2017
$490k
NATURAL HISTORY OF DEPRESSION IN ADOLESCENTSR01MH050522 · NIMH · OREGON RESEARCH INSTITUTE · PI LEWINSOHN, PETER M. · 1993 to 2001
$121k
ADOLESCENT DEPRESSION: PREVALENCE &PSYCHOSOCIAL ASPECTSR01MH040501 · NIMH · OREGON RESEARCH INSTITUTE · PI LEWINSOHN, PETER M. · 1986 to 1990
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NIAAA NIH HHS R01 AA023842NIMH NIH HHS R01 MH040501NIMH NIH HHS R01 MH050522
6 · The paper itself

Abstract

objectiveWe investigated associations between the number of parents with histories of alcohol use disorder (AUD) and several offspring (proband) variables through age 30: occurrence of AUD and, separately, alcohol dependence; onset age of the initial AUD episode; time to recovery from the first AUD episode; number of distinct AUD episodes; and cumulative duration of AUD across episodes.

methodsOffspring data were collected during four assessment waves of a longitudinal epidemiological study of psychiatric disorders with a regionally representative sample. The reference sample included 730 offspring with diagnostic data from at least one parent. Offspring were assessed with semi-structured diagnostic interviews between mid-adolescence and young adulthood and parents were assessed when offspring were approximately 24 years of age.

resultsAs the number of parents with AUD increased, offspring risk for AUD and alcohol dependence also increased. Latent growth model results indicated that offspring AUD risk trajectories increase in severity as a function of the number of parents with AUD. This pattern of results was not observed for other AUD course-related features in offspring (i.e., number of distinct episodes; months required for recovery from initial episode; cumulative duration across episodes).

conclusionsThe number of parents with a history of AUD is associated with overall offspring risk for AUD and alcohol dependence and elevated AUD risk trajectories through age 30. The number of parents with AUD may be a more relevant risk factor for onset-related characteristics of AUD in offspring than for its longitudinal course.

Indexed as

ParentsAdolescentAdultAlcoholismChild of Impaired ParentsFemaleHumansMaleProspective StudiesRiskSeverity of Illness IndexSex FactorsYoung AdultAlcohol use disorders (AUD)Clinical featuresNumber of parentsParental AUDTrajectories

Identifiers

PMID31783247
PMCPMC6934894

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.