ArticleInternational journal of psychophysiology : official journal of the International Organization of Psychophysiology2020
Variable symptomatic and neurophysiologic response to HD-tDCS in a case series with posttraumatic stress disorder.
Article in International journal of psychophysiology : official journal of the International Organization of Psychophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- The Therapeutic Effect of High-definition 1-Hz Transcranial Alternating Current Stimulation in PTSD: A Randomized Controlled Trial.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025Article
- A review on the reporting and assessment of adverse effects associated with high-definition transcranial direct current stimulation.Frontiers in human neuroscience · 2025Review
- Contemporary Approaches Toward Neuromodulation of Fear Extinction and Its Underlying Neural Circuits.Current topics in behavioral neurosciences · 2023Article
- Task-Related Hemodynamic Changes Induced by High-Definition Transcranial Direct Current Stimulation in Chronic Stroke Patients: An Uncontrolled Pilot fNIRS Study.Brain sciences · 2022Article
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Authors and funding
7 authors.
Funding
Abstract
Chronic Posttraumatic stress disorder (PTSD), characterized by symptoms of re-experiencing, hyperarousal, and avoidance, is challenging to treat as a significant proportion of patients remain symptomatic following even empirically supported interventions. The current case series investigated the effects of up to 10 sessions of high definition transcranial direct current stimulation (HD-tDCS) on symptoms of PTSD. Participants received HD-tDCS that targeted the right lateral temporal cortex (LTC; center cathode placed over T8), given this region's potential involvement in symptoms of re-experiencing and, possibly, hyperarousal. Five of the six enrolled patients completed at least 8 sessions. Of these five, four showed improvement in symptoms of re-experiencing after HD-tDCS. This improvement was accompanied by connectivity change in the right LTC as well as a larger extended fear network but not a control network that consisted of visual cortex regions; however, the nature of the change varied across participants as some showed increased connectivity whereas others showed decreased connectivity. These preliminary data suggest that HD-tDCS may be beneficial for treatment of specific PTSD symptoms, in at least some individuals, and warrants further investigation.
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