ArticleBrain research2020
Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway.
Article in Brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Suggestive Association Between Tryptophan-indole Metabolic Pathway and Total Joint Arthroplasty Early Revision for Heterogeneous Failure Modes in Patients With Primary Osteoarthritis: A Meta-analysis of Metabolomics.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2026Pooled it
- Serum metabolomic profiling reveals load-specific adaptations to resistance training.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Nutrition in the prevention and treatment of pelvic inflammatory disease: a review.Frontiers in nutrition · 2026Review
- The Interplay of Dietary Choline and Methyl Donors in Modulating Maternal Inflammation: Insights from Project Viva.The Journal of nutrition · 2025Article
- The Role of Alpha-7 Nicotinic Acetylcholine Receptors in Pain: Potential Therapeutic Implications.Current neuropharmacology · 2025Review
- Nitric Oxide Synthases in Rheumatoid Arthritis.Molecules (Basel, Switzerland) · 2023Review
- Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain.Neural regeneration research · 2023Review
- ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential.Cells · 2022Review
- Lactoferrin and Its Potential Impact for the Relief of Pain: A Preclinical Approach.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Nitric Oxide Interaction with the Eye.Vision (Basel, Switzerland) · 2021Review
- Role of Choline in Ocular Diseases.International journal of molecular sciences · 2021Review
- Atorvastatin prevents the development of diabetic neuropathic nociception by possible involvement of nitrergic system.Journal of applied biomedicine · 2021Article
- Neurobiological effects of phospholipidsNeurobiology of stress · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
New findings on neural regulation of immunity are allowing the design of novel pharmacological strategies to control inflammation and nociception. Herein, we report that choline, a 7-nicotinic acetylcholine receptor (α7nAChRs) agonist, prevents carrageenan-induced hyperalgesia without affecting inflammatory parameters (neutrophil migration or cytokine/chemokines production) or inducing sedation or even motor impairment. Choline also attenuates prostaglandin-E
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.