Evidence map›Paper›PMID 31782879›Full record

ArticlePediatric diabetes2020

Factors predicting poor glycemic control in the first two years of childhood onset type 1 diabetes in a cohort from East London, UK: Analyses using mixed effects fractional polynomial models.

Veena Mazarello Paes, Jessica K Barrett, David B Dunger, Evelien F Gevers, David C Taylor-Robinson, Russell M Viner, Terence J Stephenson

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Veena Mazarello PaesPopulation, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.ORCID 0000-0002-4283-6266
Jessica K BarrettMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
David B DungerDepartment of Paediatrics, University of Cambridge, Cambridge, UK.ORCID 0000-0002-2566-9304
Evelien F GeversCentre for Endocrinology, William Harvey Research Institute, Queen Mary University, London, UK.
David C Taylor-RobinsonDepartment of Public Health and Policy, University of Liverpool, Liverpool, UK.
Russell M VinerPopulation, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
Terence J StephensonPopulation, Policy and Practice Research and Teaching Department, UCL Great Ormond Street Institute of Child Health, University College London, London, UK.
University of Cambridge · GBGreat Ormond Street Hospital · GBBarts Health NHS Trust · GBUniversity of Liverpool · GB

Funding

Department of HealthMedical Research Council G0802448Medical Research Council MC_UU_00002/5Medical Research Council MR/P008577/1
6 · The paper itself

Abstract

BACKGROUND/

objectivePoor early glycemic control in childhood onset type 1 diabetes (T1D) is associated with future risk of acute and chronic complications. Our aim was to identify the predictors of higher glycated hemoglobin (HbA1c) within 24 months of T1D diagnosis in children and adolescents.

methodsMixed effects models with fractional polynomials were used to analyze longitudinal data of patients <19 years of age, followed from T1D diagnosis for up to 2 years, at three diabetes clinics in East London, United Kingdom.

resultsA total of 2209 HbA1c observations were available for 356 patients (52.5% female; 64.4% non-white), followed from within 3 months of diagnosis during years 2005 to 2015, with a mean ± SD of 6.2 ± 2.5 HbA1c observations/participant. The mean age and HbA1c at diagnosis were 8.9 ± 4.3 years and 10.7% ±4.3% (or expressed as mmol/mol HbA1c mean ± SD 92.9 ± 23.10 mmol/mol) respectively. Over the 2 years following T1D diagnosis, HbA1c levels were mostly above the National Institute for Health, Care and Excellence (NICE), UK recommendations of 7.5% (<58 mmol/mol). Significant (P < .05) predictors of poorer glycemic control were: Age at diagnosis (12-18 years), higher HbA1c at baseline (>9.5%, ie, >80 mmol/mol), clinic site, non-white ethnicity, and period (pre-year 2011) of diagnosis. Additionally in univariable analyses, frequency of clinic visits, HbA1c at diagnosis, and type of insulin treatment regimen showed association with poor glycemic control (P < .05).

conclusionsMajor risk factors of poorer glycemic control during 3-24 months following childhood onset T1D are: diagnosis prior to 2011, higher HbA1c levels at baseline, age at diagnosis, non-white ethnicity, and clinic site.

Indexed as

Glycemic ControlAdolescentChildChild, PreschoolDiabetes Mellitus, Type 1FemaleGlycated HemoglobinHumansHypoglycemic AgentsInfantInsulinMaleModels, StatisticalRetrospective StudiesGlycated Hemoglobinhemoglobin A1c protein, humanHypoglycemic AgentsInsulinHbA1clongitudinal analysespediatricpredictorstype 1 diabetes mellitus

Identifiers

PMID31782879
PMCPMC7028081
OpenAlexW2990836878

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.