ArticleHuman brain mapping2020
Post-stroke cognitive deficits rarely come alone: Handling co-morbidity in lesion-behaviour mapping.
Article in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- How covariate control can bias our insights into brain architecture and pathology.Scientific reports · 2026Article
- The neuroanatomy of visual extinction following right hemisphere brain damage: Insights from multivariate and Bayesian lesion analyses in acute stroke.Human brain mapping · 2024Article
- Mapping sentence comprehension and syntactic complexity: evidence from 131 stroke survivors.Brain communications · 2024Article
- Disentangling poststroke cognitive deficits and their neuroanatomical correlates through combined multivariable and multioutcome lesion-symptom mapping.Human brain mapping · 2023Article
- A fronto-insular-parietal network for the sense of body ownership.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Interpreting and validating complexity and causality in lesion-symptom prognoses.Brain communications · 2023Review
- Disconnections in personal neglect.Brain structure & function · 2022Article
- French Phonological Component Analysis and aphasia recovery: A bilingual perspective on behavioral and structural data.Frontiers in human neuroscience · 2022Article
- Mapping the human praxis network: an investigation of white matter disconnection in limb apraxia of gesture production.Brain communications · 2022Article
- The relationship between motor pathway damage and flexion-extension patterns of muscle co-excitation during walking.Frontiers in neurology · 2022Article
- Post-stroke cognitive deficits rarely come alone: Handling co-morbidity in lesion-behaviour mapping.Human brain mapping · 2020Article
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Authors and funding
3 authors.
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Abstract
Post-stroke behavioural symptoms often correlate and systematically co-occur with each other, either because they share cognitive processes, or because their neural correlates are often damaged together. Thus, neuropsychological symptoms often share variance. Many previous lesion-behaviour mapping studies aimed to methodologically consider this shared variance between neuropsychological variables. A first group of studies controlled the behavioural target variable for the variance explained by one or multiple other variables to obtain a more precise mapping of the target variable. A second group of studies focused on the shared variance of multiple variables itself with the aim to map neural correlates of cognitive processes that are shared between the original variables. In the present study, we tested the validity of these methods by using real lesion data and both real and simulated data sets. We show that the variance that is shared between post-stroke behavioural variables is ambiguous, and that mapping procedures that consider this variance are prone to biases and artefacts. We discuss under which conditions such procedures could still be used and what alternative approaches exist.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.