ReviewAdvanced materials (Deerfield Beach, Fla.)2020
In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays.
Review in Advanced materials (Deerfield Beach, Fla.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Article
- Surface-Enhanced Raman Spectroscopy for Viral Diagnostics: Principles, Strategies, Clinical Challenges, and Future Directions.Chemical reviews · 2026Review
- Molecular Design of Thermoresponsive Poly(oligoethylene glycol)vinyl Esters for the Generation of Polymer Brush-Based Biointerfaces.ACS polymers Au · 2026Article
- Kinetics of droplet cloaking and wetting ridge growth on lubricated polymer brushes.The European physical journal. E, Soft matter · 2026Article
- Responsive Polyelectrolyte Brushes in Applications: Functions, Stimuli, and Design Considerations.Advanced materials (Deerfield Beach, Fla.) · 2025Review
- Nonfouling Coatings from Synthetic Intrinsically Disordered Proteins.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Thermally Activated Swelling and Wetting Transition of Frozen Polymer Brushes:a New Concept for Surface Functionalization.Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Universal membranization of synthetic coacervates and biomolecular condensates towards ultrastability and spontaneous emulsification.Nature chemistry · 2025Article
- Dipolar Brush Polymers: A Numerical Study of the Force Exerted onto a Penetrating Colloidal Particle Under an External Field.Polymers · 2025Article
- Integrating Protein Language Model and Molecular Dynamics Simulations to Discover Antibiofouling Peptides.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- A passive blood separation sensing platform for point-of-care devices.Npj biosensing · 2025Article
- Microfluidic Chip-Assisted Upconversion Luminescence Biosensing Platform for Point-of-Care Virus Diagnostics.Advanced healthcare materials · 2024Article
- Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.Advanced materials (Deerfield Beach, Fla.) · 2023Review
- Engineering Innovative Interfaces for Point-of-Care Diagnostics.Current opinion in colloid & interface science · 2023Review
- COVID-19 Diagnosis and SARS-CoV-2 Strain Identification by a Rapid, Multiplexed, Point-of-Care Antibody Microarray.Analytical chemistry · 2023Article
- Pore performance: artificial nanoscale constructs that mimic the biomolecular transport of the nuclear pore complex.Nanoscale advances · 2022Review
- Article
- Technologies for Frugal and Sensitive Point-of-Care Immunoassays.Annual review of analytical chemistry (Palo Alto, Calif.) · 2022Review
- Review
- Rapid test to assess the escape of SARS-CoV-2 variants of concern.Science advances · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
"Nonfouling" polymer brush surfaces can greatly improve the performance of in vitro diagnostic (IVD) assays due to the reduction of nonspecific protein adsorption and consequent improvement of signal-to-noise ratios. The development of synthetic polymer brush architectures that suppress adventitious protein adsorption is reviewed, and their integration into surface plasmon resonance and fluorescent sandwich immunoassay formats is discussed. Also, highlighted is a novel, self-contained immunoassay platform (the D4 assay) that transforms time-consuming laboratory-based assays into a user-friendly and point-of-care format with a sensitivity and specificity comparable or better than standard enzyme-linked immunosorbent assay (ELISA) directly from unprocessed samples. These advancements clearly demonstrate the utility of nonfouling polymer brushes as a substrate for ultrasensitive and robust diagnostic assays that may be suitable for clinical testing, in field and laboratory settings.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.