ArticleThe European journal of neuroscience2020
Anxious to see you: Neuroendocrine mechanisms of social vigilance and anxiety during adolescence.
Article in The European journal of neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Physical Activity as a Treatment for Social Anxiety in Clinical and Non-clinical Populations: A Systematic Review and Three Meta-Analyses for Different Study Designs.Frontiers in human neuroscience · 2021Pooled it
- Article
- Short-term longitudinal associations among parent-child relationship quality, internalizing and externalizing problems, and belief in a just world: a three-wave RI-CLPM.Frontiers in psychology · 2026Article
- CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice.Hormones and behavior · 2025Article
- Bidirectional Relations between Belief in a Just World and Internalizing and Externalizing Problems among Chinese Secondary Vocational Students.Journal of youth and adolescence · 2025Article
- CRISPR-mediated knockdown of oxytocin receptor in extended amygdala reduces stress-induced social avoidance in female California mice.bioRxiv : the preprint server for biology · 2025Article
- Diminished Social Memory and Hippocampal Correlates of Social Interactions in Chronic Social Defeat Stress Susceptibility.Biological psychiatry global open science · 2025Article
- Acute and vicarious effects of social defeat stress on social behaviour in California mice,Animal behaviour · 2025Article
- Activation of androgen receptor-expressing neurons in the posterior medial amygdala is associated with stress resistance in dominant male hamsters.Hormones and behavior · 2024Article
- Androgen regulation of behavioral stress responses and the hypothalamic-pituitary-adrenal axis.Hormones and behavior · 2024Review
- Leveraging the unique social organization of California mice to study circuit-specific effects of oxytocin on behavior.Hormones and behavior · 2024Review
- Beyond fur color: differences in socio-emotional behavior and the oxytocin system between male BL6 and CD1 mice in adolescence and adulthood.Frontiers in neuroscience · 2024Article
- Nature and nurture: Comparing mouse behavior in classic versus revised anxiety-like and social behavioral assays in genetically or environmentally defined groups.Genes, brain, and behavior · 2023Article
- Paternal deprivation induces vigilance-avoidant behavior and accompanies sex-specific alterations in stress reactivity and central proinflammatory cytokine response in California mice (Peromyscus californicus).Psychopharmacology · 2023Article
- Sexual differentiation of neural mechanisms of stress sensitivity during puberty.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- The Development of Shyness from Late Childhood to Adolescence: A Longitudinal Study of Mexican-origin Youth.Social psychological and personality science · 2023Article
- Versatile, vigilance, and gut microbiome support the priority of high-ranking hens.Frontiers in veterinary science · 2023Article
- Comparative Transcriptional Analyses in the Nucleus Accumbens Identifies RGS2 as a Key Mediator of Depression-Related Behavior.Biological psychiatry · 2022Article
- Fluorescence Imaging of Neural Activity, Neurochemical Dynamics, and Drug-Specific Receptor Conformation with Genetically Encoded Sensors.Annual review of neuroscience · 2022Review
- Quantifying Sex Differences in Behavior in the Era of "Big" Data.Cold Spring Harbor perspectives in biology · 2022Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Social vigilance is a behavioral strategy commonly used in adverse or changing social environments. In animals, a combination of avoidance and vigilance allows an individual to evade potentially dangerous confrontations while monitoring the social environment to identify favorable changes. However, prolonged use of this behavioral strategy in humans is associated with increased risk of anxiety disorders, a major burden for human health. Elucidating the mechanisms of social vigilance in animals could provide important clues for new treatment strategies for social anxiety. Importantly, during adolescence the prevalence of social anxiety increases significantly. We hypothesize that many of the actions typically characterized as anxiety behaviors begin to emerge during this time as strategies for navigating more complex social structures. Here, we consider how the social environment and the pubertal transition shape neural circuits that modulate social vigilance, focusing on the bed nucleus of the stria terminalis and prefrontal cortex. The emergence of gonadal hormone secretion during adolescence has important effects on the function and structure of these circuits, and may play a role in the emergence of a notable sex difference in anxiety rates across adolescence. However, the significance of these changes in the context of anxiety is still uncertain, as not enough studies are sufficiently powered to evaluate sex as a biological variable. We conclude that greater integration between human and animal models will aid the development of more effective strategies for treating social anxiety.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.