Evidence map›Paper›PMID 31782731›Full record

ArticleeLife2019

Characterizing causality in cancer.

Elena Rondeau, Nicolas Larmonier, Thomas Pradeu, Andreas Bikfalvi

Abstract read
In one paragraph

Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Reuniting philosophy and science to advance cancer research.Biological reviews of the Cambridge Philosophical Society · 2023
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elena RondeauUniversity of Bordeaux, Bordeaux, France.
Nicolas LarmonierUniversity of Bordeaux, Bordeaux, France.
Thomas Pradeu *University of Bordeaux, Bordeaux, France.ORCID 0000-0002-6590-3281
Andreas Bikfalvi *University of Bordeaux, Bordeaux, France.ORCID 0000-0003-4138-5229

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Philosophers have explored the concept of causality for centuries. Here we argue that ideas about causality from philosophy can help scientists to better understand how cancerous tumors grow and spread in the body. After outlining six characteristics of causality that are relevant to cancer, we emphasize the importance of feedback loops and interactions between tumor-cell-intrinsic and tumor-cell-extrinsic factors for explaining the formation and dissemination of tumors.

Indexed as

CausalityHumansNeoplasmscancer biologycarcinogenesiscausalitymetastasisphilosophy of biology

Identifiers

PMID31782731
PMCPMC6884405

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.