ArticleJournal of the American Chemical Society2019
Polymerization-Induced Polymersome Fusion.
Article in Journal of the American Chemical Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Constructing and decoding tree-ring-like surface patterns on self-assembled polymer platelets.Nature communications · 2026Article
- Temperature-Induced Morphological Transitions for On-Demand Detachment in Worm-Based Polymer Hydrogels.Angewandte Chemie (International ed. in English) · 2026Article
- Kinetically controlled hetero-fusion is a systems-level behaviour of polymer nanoparticle populations.Nature communications · 2025Article
- Solvent-Induced Morphology Control of Polymer Assemblies with Improved Photothermal Features.Journal of the American Chemical Society · 2025Article
- Polymersome-based nanomotors: preparation, motion control, and biomedical applications.Chemical science · 2025Review
- Biomimetic Materials to Fabricate Artificial Cells.Chemical reviews · 2024Review
- Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution.Journal of the American Chemical Society · 2024Review
- Modern Trends in Polymerization-Induced Self-Assembly.Polymers · 2024Review
- Shape Transformation of Polymer Vesicles.Accounts of materials research · 2024Article
- Controlled node growth on the surface of polymersomes.Chemical science · 2024Article
- Polymersomes as the Next Attractive Generation of Drug Delivery Systems: Definition, Synthesis and Applications.Materials (Basel, Switzerland) · 2024Review
- Probing Catalyst Degradation in Metathesis of Internal Olefins: Expanding Access to Amine-Tagged ROMP Polymers.ACS catalysis · 2023Article
- Triggered Polymersome Fusion.Journal of the American Chemical Society · 2023Article
- The Janus face of high trans-effect carbenes in olefin metathesis: gateway to both productivity and decomposition.Chemical science · 2022Article
- Lateral growth of cylinders.Nature communications · 2022Article
- En route to dynamic life processes by SNARE-mediated fusion of polymer and hybrid membranes.Nature communications · 2021Article
- Bimolecular Coupling in Olefin Metathesis: Correlating Structure and Decomposition for Leading and Emerging Ruthenium-Carbene Catalysts.Journal of the American Chemical Society · 2021Article
- Routes to High-Performing Ruthenium-Iodide Catalysts for Olefin Metathesis: Ligand Lability Is Key to Efficient Halide Exchange.Organometallics · 2021Article
- The Impact of Water on Ru-Catalyzed Olefin Metathesis: Potent Deactivating Effects Even at Low Water Concentrations.ACS catalysis · 2021Article
- Directional effect on the fusion of ellipsoidal morphologies into nanorods and nanotubes.RSC advances · 2021Article
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Authors and funding
6 authors.
Funding
Abstract
The dynamic interactions of membranes, particularly their fusion and fission, are critical for the transmission of chemical information between cells. Fusion is primarily driven by membrane tension built up through membrane deformation. For artificial polymersomes, fusion is commonly induced via the external application of a force field. Herein, fusion-promoted development of anisotropic tubular polymersomes (tubesomes) was achieved in the absence of an external force by exploiting the unique features of aqueous ring-opening metathesis polymerization-induced self-assembly (ROMPISA). The out-of-equilibrium tubesome morphology was found to arise spontaneously during polymerization, and the composition of each tubesome sample (purity and length distribution) could be manipulated simply by targeting different core-block degrees of polymerization (DPs). The evolution of tubesomes was shown to occur via fusion of "monomeric" spherical polymersomes, evidenced most notably by a step-growth-like relationship between the fraction of tubular to spherical nano-objects and the average number of fused particles per tubesome (analogous to monomer conversion and DP, respectively). Fusion was also confirmed by Förster resonance energy transfer (FRET) studies to show membrane blending and confocal microscopy imaging to show mixing of the polymersome lumens. We term this unique phenomenon polymerization-induced polymersome fusion, which operates via the buildup of membrane tension exerted by the growing polymer chains. Given the growing body of evidence demonstrating the importance of nanoparticle shape on biological activity, our methodology provides a facile route to reproducibly obtain samples containing mixtures of spherical and tubular polymersomes, or pure samples of tubesomes, of programmed length. Moreover, the capability to mix the interior aqueous compartments of polymersomes during polymerization-induced fusion also presents opportunities for its application in catalysis, small molecule trafficking, and drug delivery.
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