ReviewPlant biotechnology journal2020
Cytokinin dehydrogenase: a genetic target for yield improvement in wheat.
Review in Plant biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 83 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
83 citing papers in PubMed, 2 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Chickpea Biofortification for Cytokinin DehydrogenaseFrontiers in genetics · 2022Pooled it
- Role of cytokinins in seed development in pulses and oilseed crops: Current status and future perspective.Frontiers in genetics · 2022Pooled it
- Knockout of TaCKX2.2 in Wheat Improved Grain Yield by Increasing Grain Number Per Spike and Grain Size Under Field Production Conditions.Plant, cell & environment · 2026Article
- Targeted Mutagenesis of CKX3 Homologs Enhances Seed Yield in Soybean.Plant, cell & environment · 2026Article
- Cultivar-dependent regulation of cytokinin biosynthesis in wheat: developmental expression of TaIPT genes and hormonal crosstalk during reproductive development.BMC plant biology · 2026Article
- Overexpression of an Alfalfa Gene,Genes · 2026Article
- Knockout of a cytokinin oxidase/dehydrogenase boosts soybean yield.Plant communications · 2026Article
- Article
- Root-specific cytokinin catabolism promotes Nicotiana root growth and resilience to drought stress.Planta · 2026Article
- Shoot transcriptome and co-expression network analysis of African rice cultivars identify drought-tolerance hub genes and growth stage-dependent trade-offs.Frontiers in plant science · 2026Article
- Knockout ofPlants (Basel, Switzerland) · 2025Article
- Validated reference genes for normalization of RT-qPCR in developing organs of wheat to study developmentally/spatio-temporally expressed family genes.Scientific reports · 2025Article
- Proteomic profiling reveals important regulators of photosynthate accumulation in wheat leaves during grain development.BMC plant biology · 2025Article
- Genome-wide analysis of AHP genes in soybean and the role of GmAHP10 in improving salt stress tolerance.Functional & integrative genomics · 2025Article
- Effects of Different Modified Biochars on Growth ofPlants (Basel, Switzerland) · 2025Article
- Genome-wide investigation of cytokinin oxidase/dehydrogenase (CKX) family genes in Brassica juncea with an emphasis on yield-influencing CKX.Scientific reports · 2025Article
- Recent innovations in crop protection research.Pest management science · 2025Review
- Deciphering the Proteome and Phosphoproteome of Peanut (International journal of molecular sciences · 2025Article
- Article
- Natural variation in LONELY GUY-Like 1 regulates rice grain weight under warmer night conditions.Plant physiology · 2024Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issuedCorrigendum.2020
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The plant hormone group, the cytokinins, is implicated in both qualitative and quantitative components of yield. Cytokinins have opposing actions in shoot and root growth-actions shown to involve cytokinin dehydrogenase (CKX), the enzyme that inactivates cytokinin. We revise and provide unambiguous names for the CKX gene family members in wheat, based on the most recently released wheat genome database, IWGSC RefSeq v1.0 & v2.0. We review expression data of CKX gene family members in wheat, revealing tissue-specific gene family member expression as well as sub-genome-specific expression. Manipulation of CKX in cereals shows clear impacts on yield, root growth and orientation, and Zn nutrition, but this also emphasizes the necessity to unlink promotive effects on grain yield from negative effects of cytokinin on root growth and uptake of mineral nutrients, particularly Zn and Fe. Wheat is the most widely grown cereal crop globally, yet is under-research compared with rice and maize. We highlight gaps in our knowledge of the involvement of CKX for wheat. We also highlight the necessity for accurate analysis of endogenous cytokinins, acknowledging why this is challenging, and provide examples where inadequate analyses of endogenous cytokinins have led to unjustified conclusions. We acknowledge that the allohexaploid nature of bread wheat poses challenges in terms of uncovering useful mutations. However, we predict TILLING followed by whole-exome sequencing will uncover informative mutations and we indicate the potential for stacking mutations within the three genomes to modify yield components. We model a wheat ideotype based on CKX manipulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.