Trial reportBritish journal of clinical pharmacology2020
Acute caffeine intake increases muscle oxygen saturation during a maximal incremental exercise test.
Trial report in British journal of clinical pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Effect of Acute Caffeine Intake on Fat Oxidation Rate during Fed-State Exercise: A Systematic Review and Meta-Analysis.Nutrients · 2024Pooled it
- Caffeine intake reverses the impairment of sleep restriction on high-intensity exercise performance.European journal of applied physiology · 2026Trial
- The effect of caffeine chewing gum on muscle performance and fatigue after severe-intensity exercise: isometric vs. dynamic assessments in trained cyclists.European journal of applied physiology · 2025Trial
- Sex differences in the acute effect of caffeine on repeated sprint performance: A randomized controlled trial.European journal of sport science · 2025Trial
- ACE gene polymorphisms (rs4340) II and DI are more responsive to the ergogenic effect of caffeine than DD on aerobic power, heart rate, and perceived exertion in a homogeneous Brazilian group of adolescent athletes.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2024Trial
- Effect of caffeine on muscle oxygen saturation during short-term all-out exercise: a double-blind randomized crossover study.European journal of nutrition · 2022Trial
- Similar ergogenic effect of caffeine on anaerobic performance in men and women athletes.European journal of nutrition · 2021Trial
- Caffeine increases whole-body fat oxidation during 1 h of cycling at Fatmax.European journal of nutrition · 2021Trial
- Trial
- Acute caffeine intake increases muscle oxygen saturation during a maximal incremental exercise test.British journal of clinical pharmacology · 2020Trial
- The effects of caffeinated chewing gum on sprint swimming performance and upper-body strength: a randomized crossover study.BMC nutrition · 2026Article
- Effects of caffeinated chewing gum on prolonged repeated-sprint performance in normobaric hypoxia.Frontiers in nutrition · 2026Article
- Acute caffeine ingestion improves sport-specific and cognitive performance in elite badminton athletes.Frontiers in nutrition · 2025Article
- Low-Dose Caffeine Supplementation Is a Valuable Strategy for Increasing Time to Exhaustion, Explosive Power, and Reducing Muscle Soreness in Professional Male Kickboxers.Current developments in nutrition · 2025Article
- Relationship among muscle strength, muscle endurance, and skeletal muscle oxygenation dynamics during ramp incremental cycle exercise.Scientific reports · 2024Article
- Diagnostic Ultrasound-Based Investigation of Central vs. Peripheral Arterial Changes Consequent to Low-Dose Caffeine Ingestion.Nutrients · 2024Article
- Yerba Maté (Nutrients · 2023Article
- Training zones through muscle oxygen saturation during a graded exercise test in cyclists and triathletes.Biology of sport · 2023Article
- Effect of Oral Caffeine on Weaning from Mechanical Ventilation in Intubated ICU Patients.Tanaffos · 2023Article
- Association of Coffee and Tea Consumption with the Risk of Asthma: A Prospective Cohort Study from the UK Biobank.Nutrients · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe main mechanism behind caffeine's ergogenicity lies in its tendency to bind to adenosine receptors, although other mechanisms might be involved. The aim of this investigation was to analyse the effects of caffeine on muscle oxygen saturation during exercise of increasing intensity.
methodsThirteen healthy and active individuals volunteered to participate in a randomized, double blind, placebo-controlled crossover trial. During 2 different trials, participants either ingested a placebo (cellulose) or 3 mg/kg of caffeine. After waiting for 60 min to absorb the substances, participants underwent a maximal ramp cycle ergometer test (25 W/min). Near infrared spectrometers were positioned on each leg's vastus lateralis to monitor tissue O
resultsIn comparison to the placebo, the ingestion of caffeine improved the maximal wattage (258 ± 50 vs 271 ± 54 W, respectively, P < .001, effect size [ES] = 0.27; 95% confidence interval [CI] 0.14-0.35) and blood lactate concentration (11.9 ± 3.8 vs 13.7 ± 3.5 mmol/L, P = .029, ES = 0.38; 95% CI 0.14-0.75) at the end of the test. Caffeine increased muscle oxygen saturation at several exercise workloads with a main effect found in respect to the placebo (F = 6.28, P = .029; ES = 0.30 to 0.54; 95% CI 0.01-0.78). Peak pulmonary ventilation (124 ± 29 vs 129 ± 23 L/min, P = 0.035, ES = 0.25; 95% CI 0.07-0.40) and peak oxygen uptake (3.18 ± 0.70 vs 3.33 ± 0.88 L/min, P = 0.032, ES = 0.26; 95% CI 0.08-0.51) were also increased with caffeine.
conclusionAcute ingestion of 3 mg/kg of caffeine improved peak aerobic performance and increased peak pulmonary ventilation. In addition, caffeine induced changes in muscle oxygen saturation during submaximal workloads, suggesting that this mechanism might also contribute to caffeine's ergogenic effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.