Evidence map›Paper›PMID 31782255›Full record

ArticlePhysiological reports2019

"A Step and a Ceiling": mechanical properties of Ca

Viktoria Csato, Sharifah Z S A Kadir, Kaivan Khavandi, Hayley Bennett, Sarah Sugden, Alison M Gurney, Harry T Pritchard, David Hill-Eubanks, Philip Eaton, Mark T Nelson and 1 more

Open access · goldAbstract read
In one paragraph

Article in Physiological reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 4 countries.

Viktoria CsatoDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
Sharifah Z S A KadirDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
Kaivan KhavandiDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
Hayley BennettDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
Sarah SugdenDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
Alison M GurneyDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
Harry T PritchardDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
David Hill-EubanksDepartment of Pharmacology, University of Vermont, Burlington, Vermont.
Philip EatonCentre for Clinical Pharmacology, William Harvey Research Institute, Queen Mary University of London, London, United Kingdom.
Mark T NelsonDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.
Adam S GreensteinDivision of Cardiovascular Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Health Innovation Manchester Network, Manchester, United Kingdom.ORCID 0000-0002-5274-4189
Manchester Academic Health Science Centre · GBUniversity of Vermont · USQueen Mary University of London · GBUniversity of Debrecen · HU

Funding

Capillaries as a Sensory Web that Controls Cerebral Blood Flow in Health and DiseaseR35HL140027 · NHLBI · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2025
$6.3M
Ion Channel Dysfunction in Small Vessel Disease of the BrainR01NS110656 · NINDS · UNIVERSITY OF VERMONT & ST AGRIC COLLEGE · PI NELSON, MARK T · 2019 to 2023
$2.6M
British Heart Foundation FS/14/26/30767British Heart Foundation PG/15/109/31931, FS/12/81/29882British Heart Foundation PG/17/44/33064British Heart Foundation PG/18/7/33535British Heart Foundation RG/17/16/33294Medical Research Council MR/P023150/2Medical Research Council MR/R01065X/1NHLBI NIH HHS R35 HL140027NINDS NIH HHS R01 NS110656
6 · The paper itself

Abstract

We investigated the biomechanical relationship between intraluminal pressure within small mesenteric resistance arteries, oxidant activation of PKG, Ca

Indexed as

AnimalsCalcium SignalingCyclic GMP-Dependent Protein KinasesEnzyme ActivationMaleMesenteric ArteriesMiceMice, Inbred C57BLMice, TransgenicMuscle, Smooth, VascularMyographyOrgan Culture TechniquesOxidantsOxidative StressVasoconstrictionCyclic GMP-Dependent Protein KinasesOxidantsCa2+ sparkoxidant signalingpressure- induced constrictionprotein kinase Gvascular smooth muscle

Identifiers

PMID31782255
PMCPMC6883097
OpenAlexW2980789386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.