Evidence map›Paper›PMID 31782092›Full record

ArticleThe journal of physiological sciences : JPS2019

Endurance running exercise is an effective alternative to estradiol replacement for restoring hyperglycemia through TBC1D1/GLUT4 pathway in skeletal muscle of ovariectomized rats.

Mizuho Kawakami, Naoko Yokota-Nakagi, Akira Takamata, Keiko Morimoto

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The journal of physiological sciences : JPS, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mizuho KawakamiDepartment of Environmental Health, Faculty of Human Life and Environment, Nara Women's University, Kita-Uoya Nishi-machi, Nara, 630-8506, Japan.
Naoko Yokota-NakagiDepartment of Environmental Health, Faculty of Human Life and Environment, Nara Women's University, Kita-Uoya Nishi-machi, Nara, 630-8506, Japan.
Akira TakamataDepartment of Environmental Health, Faculty of Human Life and Environment, Nara Women's University, Kita-Uoya Nishi-machi, Nara, 630-8506, Japan.
Keiko MorimotoDepartment of Environmental Health, Faculty of Human Life and Environment, Nara Women's University, Kita-Uoya Nishi-machi, Nara, 630-8506, Japan. kmorimot@cc.nara-wu.ac.jp.
Nara Women's University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Menopause is a risk factor for impaired glucose metabolism. Alternative treatment of estrogen for postmenopausal women is required. The present study was designed to investigate the effects of 5-week endurance running exercise (Ex) by treadmill on hyperglycemia and signal pathway components mediating glucose transport in ovariectomized (OVX) placebo-treated rats, compared with 4-week 17β-estradiol (E2) replacement or pair-feeding (PF) to the E2 group. Ex improved the hyperglycemia and insulin resistance index in OVX rats as much as E2 or PF did. However, Ex had no effect on body weight gain in the OVX rats. Moreover, Ex enhanced the levels of GLUT4 and phospho-TBC1D1 proteins in the gastrocnemius of the OVX rats, but E2 or PF did not. Instead, the E2 increased the Akt2/AS160 expression and activation in the OVX rats. This study suggests that endurance Ex training restored hyperglycemia through the TBC1D1/GLUT4 pathway in muscle by an alternative mechanism to E2 replacement.

Indexed as

Physical Conditioning, AnimalPhysical EnduranceRunningAnimalsBody CompositionEstradiolFeeding BehaviorFemaleGene Expression RegulationGlucoseGlucose Transporter Type 4Muscle, SkeletalOvariectomyProteinsRatsSignal TransductionEstradiolGlucoseGlucose Transporter Type 4ProteinsSlc2a4 protein, ratTBC1D1 protein, ratEstradiol replacementHyperglycemiaInsulin resistanceOvariectomized ratRunning exercise trainingTBC1D1/GLUT4 pathway

Identifiers

PMID31782092
PMCPMC10717071
OpenAlexW2989822317

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.