Evidence map›Paper›PMID 31782038›Full record

ArticleMetabolic brain disease2020

Prior exercise protects against oxidative stress and motor deficit in a rat model of Parkinson's disease.

Leonam Oliver Durval Oliveira, Pedro Iuri Castro da Silva, Renato Pereira Rodrigues Filho, Raphaely Cristiny Sanches Progênio, Victor Douglas Pereira Silva de Oliveira, Renata Cunha Silva, Mariseth Carvalho de Andrade, Jofre Jacob da Silva Freitas, Katia Simone Kietzer

Abstract read
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In one paragraph

Article in Metabolic brain disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Leonam Oliver Durval OliveiraLaboratory of Morphophysiology Applied to Health, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil. leonam.durval@gmail.com.ORCID 0000-0001-6861-1164
Pedro Iuri Castro da SilvaLaboratory of Morphophysiology Applied to Health, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Renato Pereira Rodrigues FilhoLaboratory of Morphophysiology Applied to Health, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Raphaely Cristiny Sanches ProgênioLaboratory of Morphophysiology Applied to Health, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Victor Douglas Pereira Silva de OliveiraLaboratory of Morphophysiology Applied to Health, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Renata Cunha SilvaLaboratory of Morphophysiology Applied to Health, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Mariseth Carvalho de AndradeLaboratory of Morphophysiology Applied to Health, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Jofre Jacob da Silva FreitasMorphology and Physiological Sciences Department, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Katia Simone KietzerMorphology and Physiological Sciences Department, University of Pará State, Perebebuí Street 2623, Marco, Belém, PA, 66087662, Brazil.
Morpho (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study investigated if a prior long-term physical exercise protocol protects the substantia nigra and the striatum against oxidative stress and motor deficits in a Parkinson Disease model induced by 6-hydroxydopamine. Three animal treatment groups were included in the study: sham; 6-hydroxydopamine and 6-hydroxydopamine/exercise. Previously to the intrastriatal lesion by 6-hydroxydopamine, rats in the exercise groups performed a swimming program for 18 weeks. The rats were submitted to behavioral tests before and after intrastriatal 6-hydroxydopamine injection. The oxidative stress was analyzed by Thiobarbituric Acid Reactive Substances and Glutathione reductase activity methods. The exercise decreased lipid peroxidation and increased glutathione reductase activity in the substantia nigra. In contrast, in the striatum, exercise increased lipid peroxidation and decreased glutathione reductase activity. Exercise increased contralateral rotations and reduces immobility levels at 14 days post lesion. The exercise prior to 6-OHDA lesion had protective action only in substantia nigra against oxidative stress.

Indexed as

AnimalsMaleMotor Skills DisordersOxidative StressOxidopamineParkinsonian DisordersPhysical Conditioning, AnimalRandom AllocationRatsRats, WistarOxidopamineExercise therapyMovement disordersOxidative stressParkinson disease

Identifiers

PMID31782038
OpenAlexW2989658927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.