Evidence map›Paper›PMID 31781896›Full record

ArticleWorld journal of urology2020

The impact of age at orchiopexy on testicular cancer outcomes.

Margaret Higgins, Derek E Smith, Dexiang Gao, Duncan Wilcox, Nicholas G Cost, Amanda F Saltzman

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Testicular ectopia: A case report.Experimental and therapeutic medicine · 2023
    Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Margaret HigginsDepartment of Urology, University of Kentucky, 800 Rose Street, MS 237, Lexington, KY, 40536, USA.
Derek E SmithDepartment of Pediatrics, University of Colorado School of Medicine and University of Colorado Cancer Center, Aurora, CO, USA.
Dexiang GaoDepartment of Pediatrics, University of Colorado School of Medicine and University of Colorado Cancer Center, Aurora, CO, USA.
Duncan WilcoxDivision of Urology, Department of Surgery, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Nicholas G CostDivision of Urology, Department of Surgery, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO, USA.
Amanda F SaltzmanDepartment of Urology, University of Kentucky, 800 Rose Street, MS 237, Lexington, KY, 40536, USA. afsaltzman@gmail.com.ORCID http://orcid.org/0000-0002-3338-1116
Children's Hospital Colorado · USUniversity of Colorado Cancer Center · USUniversity of Kentucky · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo estimate how many boys with UDT must undergo orchiopexy to prevent one case of TC, one death from TC and one exposure to TC treatment beyond radical orchiectomy as compared to being treated at an older age.

methodsThis retrospective study utilized data from a 2007 Swedish study of males who underwent orchiopexy for UDT (Pettersson et al.). TC incidence for boys undergoing orchiopexy for UDT was assessed based on the age at orchiopexy (0-6 years, 7-9 years, 10-12 years, 13-15 years). The incidence of TC in each age cohort was calculated and used to determine the number needed to treat (NNT) for each age group using assumptions based on published TC outcomes.

resultsFor an index patient ≤ 6 years, 372 boys need to undergo orchiopexy to prevent a single case of TC, 1488 boys to prevent exposure to TC therapy beyond radical orchiectomy, and 5315 boys to prevent a single TC-related death compared to treatment at an older age.

conclusionWhile there is evidence supporting benefits of early orchiopexy, the NNT to affect TC outcomes is very high. Even those with delayed orchiopexies have low risk for TC poor outcomes. This information can be used when counseling patients and families faced with UDT about the risks related to TC, especially with comorbidities.

Indexed as

OrchiopexyAdolescentAge FactorsChildChild, PreschoolCryptorchidismHumansIncidenceInfantMaleRetrospective StudiesTesticular NeoplasmsTreatment OutcomeYoung AdultNumber needed to treatOrchiopexyTesticular cancerUndescended testicle

Identifiers

PMID31781896
OpenAlexW2990758892

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.