ReviewEpidemiologic reviews2019
A Review of Asymptomatic and Subclinical Middle East Respiratory Syndrome Coronavirus Infections.
Review in Epidemiologic reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- Human coronaviruses: activation and antagonism of innate immune responses.Microbiology and molecular biology reviews : MMBR · 2025Review
- Individual Immune Response to SARS-CoV-2 Infection-The Role of Seasonal Coronaviruses and Human Leukocyte Antigen.Biology · 2023Article
- Replicating superspreader dynamics with compartmental models.Scientific reports · 2023Article
- What is the burden of asymptomatic coronavirus infections?New microbes and new infections · 2023Article
- New endemic and pandemic pathologies with interhuman airborne transmission through ear, nose and throat anatomical sites.Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale · 2022Article
- Genomic Diversity of SARS-CoV-2 in Algeria and North African Countries: What We Know So Far and What We Expect?Microorganisms · 2022Article
- Unresolved questions in the zoonotic transmission of MERS.Current opinion in virology · 2022Review
- Asymptomatic Transmissibility Calls for Implementing a Zero-COVID Strategy to End the Current Global Crisis.Frontiers in cellular and infection microbiology · 2022Article
- Article
- Low-Level Middle East Respiratory Syndrome Coronavirus among Camel Handlers, Kenya, 2019.Emerging infectious diseases · 2021Article
- Mathematical modeling applied to epidemics: an overview.The Sao Paulo journal of mathematical sciences · 2021Article
- Invisible epidemics: ethics and asymptomatic infection.Monash bioethics review · 2020Review
- Lessons from SARS-CoV-2 screening in a Brazilian organ transplant unit.Transplant infectious disease : an official journal of the Transplantation Society · 2020Article
- Features of enteric disease from human coronaviruses: Implications for COVID-19.Journal of medical virology · 2020Review
- A comparative overview of COVID-19, MERS and SARS: Review article.International journal of surgery (London, England) · 2020Review
- Correct management and low rate of contagiousness of healthcare workers in a University Hospital in Southern Italy: from contact tracing to serological investigation.Acta bio-medica : Atenei Parmensis · 2020Article
- The implications of preliminary screening and diagnosis: Clinical characteristics of 33 mild patients with SARS-CoV-2 infection in Hunan, China.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2020Article
- First respiratory transmitted food borne outbreak?International journal of hygiene and environmental health · 2020Article
- Middle East respiratory syndrome.Lancet (London, England) · 2020Review
- Individuals with covert severe acute respiratory syndrome coronavirus 2 infection: Are they a critical booby-trap?Revista da Sociedade Brasileira de Medicina Tropical · 2020Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The epidemiology of Middle East respiratory syndrome coronavirus (MERS-CoV) since 2012 has been largely characterized by recurrent zoonotic spillover from dromedary camels followed by limited human-to-human transmission, predominantly in health-care settings. The full extent of infection of MERS-CoV is not clear, nor is the extent and/or role of asymptomatic infections in transmission. We conducted a review of molecular and serological investigations through PubMed and EMBASE from September 2012 to November 15, 2018, to measure subclinical or asymptomatic MERS-CoV infection within and outside of health-care settings. We performed retrospective analysis of laboratory-confirmed MERS-CoV infections reported to the World Health Organization to November 27, 2018, to summarize what is known about asymptomatic infections identified through national surveillance systems. We identified 23 studies reporting evidence of MERS-CoV infection outside of health-care settings, mainly of camel workers, with seroprevalence ranges of 0%-67% depending on the study location. We identified 20 studies in health-care settings of health-care worker (HCW) and family contacts, of which 11 documented molecular evidence of MERS-CoV infection among asymptomatic contacts. Since 2012, 298 laboratory-confirmed cases were reported as asymptomatic to the World Health Organization, 164 of whom were HCWs. The potential to transmit MERS-CoV to others has been demonstrated in viral-shedding studies of asymptomatic MERS infections. Our results highlight the possibility for onward transmission of MERS-CoV from asymptomatic individuals. Screening of HCW contacts of patients with confirmed MERS-CoV is currently recommended, but systematic screening of non-HCW contacts outside of health-care facilities should be encouraged.
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