ReviewThe international journal of neuropsychopharmacology2020
Candidate Biomarkers of Suicide Crisis Syndrome: What to Test Next? A Concept Paper.
Review in The international journal of neuropsychopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Genetic variations related to inflammation in suicidal ideation and behavior: A systematic review.Frontiers in psychiatry · 2022Pooled it
- Clinical Utility of Functional Near-Infrared Spectroscopy for Assessment and Prediction of Suicidality: A Systematic Review.Frontiers in psychiatry · 2021Pooled it
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Suicide Crisis Syndrome: examining supporting evidence and barriers to diagnostic validity.Frontiers in psychiatry · 2025Article
- Latent groups from multidimensional factors and effects on suicidal ideation in older adults.BJPsych open · 2024Article
- Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- Risk-Taking Behavior among Suicide Attempters.Journal of clinical medicine · 2022Article
- Family connections vs treatment at usual optimized in the treatment of relatives of people with suicidal behavior disorder: study protocol of a randomized control trial.BMC psychiatry · 2022Article
- Psychological impact of COVID-19 restrictions among individuals at risk of exercise addiction and their socio-demographic correlates: A Saudi Arabian survey study.Current psychology (New Brunswick, N.J.) · 2022Article
- The Role of the Lateral Habenula in Suicide: A Call for Further Exploration.Frontiers in behavioral neuroscience · 2022Review
- Network science approach elucidates integrative genomic-metabolomic signature of antidepressant response and lifetime history of attempted suicide in adults with major depressive disorder.Frontiers in pharmacology · 2022Article
- Development of Autonomic Nervous System Assays as Point-of-Care Tests to Supplement Clinical Judgment in Risk Assessment for Suicidal Behavior: A Review.Current psychiatry reports · 2022Review
- The association between the suicide crisis syndrome and suicidal behaviors: The moderating role of personality traits.European psychiatry : the journal of the Association of European Psychiatrists · 2021Article
- Prevention of Suicidal Relapses in Adolescents With a Smartphone Application: Bayesian Network Analysis of a Preclinical Trial Using In Silico Patient Simulations.Journal of medical Internet research · 2021Article
- Review
- Fatigue and brain arousal in patients with major depressive disorder.European archives of psychiatry and clinical neuroscience · 2021Article
- Identification of Risk Factors to Predict the Occurrences of Relapses in Individuals with Schizophrenia Spectrum Disorder in Iran.International journal of environmental research and public health · 2021Article
- Suicidality and Cannabidiol: Opportunities and Challenges.Current neuropharmacology · 2021Article
- Suicide Risk Assessment and Prevention: Challenges and Opportunities.Focus (American Psychiatric Publishing) · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere has been increasing interest in both suicide-specific diagnoses within the psychiatric nomenclature and related biomarkers. Because the Suicide Crisis Syndrome-an emotional crescendo of several interrelated symptoms-seems to be promising for the identification of individuals at risk of suicide, the aim of the present paper is to review the putative biological underpinnings of the Suicide Crisis Syndrome symptoms (entrapment, affective disturbance, loss of cognitive control, hyperarousal, social withdrawal).
methodsA PubMed literature search was performed to identify studies reporting a link between each of the 5 Suicide Crisis Syndrome symptoms and biomarkers previously reported to be associated with suicidal outcomes.
resultsDisturbances in the hypothalamic-pituitary-adrenal axis, with dysregulated corticotropin-releasing hormone and cortisol levels, may be linked to a sense of entrapment. Affective disturbance is likely mediated by alterations in dopaminergic circuits involved in reward and antireward systems as well as endogenous opioids. Loss of cognitive control is linked to altered neurocognitive function in the areas of executive function, attention, and decision-making. Hyperarousal is linked to autonomic dysregulation, which may be characterized by a reduction in both heart rate variability and electrodermal activity. Social withdrawal has been associated with oxytocin availability. There is also evidence that inflammatory processes may contribute to individual Suicide Crisis Syndrome symptoms.
conclusionThe Suicide Crisis Syndrome is a complex syndrome that is likely the consequence of distinct changes in interconnected neural, neuroendocrine, and autonomic systems. Available clinical and research data allow for development of empirically testable hypotheses and experimental paradigms to scrutinize the biological substrates of the Suicide Crisis Syndrome.
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