ArticleThe journal of nutrition, health & aging2019
Is Polypharmacy Associated with Cognitive Frailty in the Elderly? Results from the Korean Frailty and Aging Cohort Study.
Article in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Polypharmacy and Hyperpolypharmacy in Older Individuals with Parkinson's Disease: A Systematic Review and Meta-Analysis.Gerontology · 2022Pooled it
- Association Between the Color Kanji Pick-Out Test App Performance and Cognitive Frailty as a Potential Early Screening Marker for Cognitive Decline.Geriatrics (Basel, Switzerland) · 2026Article
- Multifactorial analysis of risk factors for frailty and cognitive frailty among hospitalized patients.BMC geriatrics · 2026Article
- Construction and validation of a predictive model for reversible cognitive frailty in elderly people in nursing homes.BMC geriatrics · 2026Article
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- Impact of Modifiable Factors Associated with Physical Frailty and Cognitive Impairment Trajectory of Older Adults: Using the Korean Longitudinal Study of Aging 2006-2018.Healthcare (Basel, Switzerland) · 2025Article
- Diagnosis of frailty and implications on surgical process in the elderly: A narrative review.European journal of anaesthesiology and intensive care · 2023Review
- Cross sectional association between cognitive frailty and disability among community-dwelling older adults: Focus on the role of social factors.Frontiers in public health · 2023Article
- The effects of interventions to enhance cognitive and physical functions in older people with cognitive frailty: a systematic review and meta-analysis.European review of aging and physical activity : official journal of the European Group for Research into Elderly and Physical Activity · 2022Review
- Health Care Utilization and Out-of-Pocket Payments among Elderly with Cognitive Frailty in Malaysia.International journal of environmental research and public health · 2022Article
- Mild behavioral impairment is related to frailty in non-dementia older adults: a cross-sectional study.BMC geriatrics · 2020Article
- Diagnosis and Management of Frailty in Primary Health Care.Korean journal of family medicine · 2020Article
- Editorial: To Drug or Not to Drug: The Geriatrician Dilemma of Polypharmacy.The journal of nutrition, health & aging · 2020Article
- Editorial: Oral Frailty.The journal of nutrition, health & aging · 2020Article
- Institutional Residence Protects Against Cognitive Frailty: A Cross-Sectional Study.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCognitive frailty-the coexistence of physical frailty and cognitive impairment-is a phenotype of frailty in the elderly. The coexistence of physical frailty and cognitive impairment, known as cognitive frailty, is one of the phenotypes of frailty in the elderly. Cognitive frailty predicts adverse health outcome more accurately than does physical frailty. In this study, we aim to determine whether the polypharmacy common among the elderly is linked with cognitive frailty. DESIGN, SETTING, AND
participantsThe elderly, aged between 70 and 84 years, who participated in the cross-sectional Korean Frailty and Aging Cohort Study were included in the present study. MEASUREMENTS: Polypharmacy and hyperpolypharmacy were defined as the use of at least five and ten medications, respectively. Physical frailty was assessed by the Korean version of the FRAIL scale, and cognitive status was measured by the Trail Making Test part A, word list recall test, the Korean version of the Frontal Assessment Battery, and the Digit Span Backward test.
resultsAmong the 2,392 participants, 26.8% and 4.1% took more than five and ten prescribed medications, respectively. Polypharmacy and hyperpolypharmacy participants tend to have more cognitive impairment and physical frailty. Participants with cognitive frailty had the highest polypharmacy rate regardless of medication type. After controlling for the potential confounders including severity of comorbidities, frailty was found to be significantly related to polypharmacy, as defined by prescribed as well as total medications, including non-prescribed medications. However, cognitive impairment only showed a linkage to polypharmacy of prescribed medications, which-according to the results of multivariable analysis- could increase cognitive frailty, with an odds ratio of 2.70.
conclusionAlthough the elderly tend to depend on various medications, they should seriously consider the risk of polypharmacy for better health outcomes.
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