ArticleThe journal of nutrition, health & aging2019
Physical Function and Strength in Relation to Inflammation in Older Adults with Obesity and Increased Cardiometabolic Risk.
Article in The journal of nutrition, health & aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Effectiveness of resistance training in modulating inflammatory biomarkers among Asian patients with sarcopenia: a systematic review and meta-analysis of randomized controlled trials.Frontiers in immunology · 2024Pooled it
- Sarcopenia as a Mediator of the Effect of a Gerontogymnastics Program on Cardiorespiratory Fitness of Overweight and Obese Older Women: A Randomized Controlled Trial.International journal of environmental research and public health · 2020Trial
- Early life adversity, educational attainment, and cardiometabolic risk among middle-aged and older adults in the United States.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Equation-derived SMI not generalizable for DXA-defined low muscle mass in Chinese adults: external validation study.Frontiers in nutrition · 2026Article
- Association between Cardiometabolic Index (CMI) with muscle mass and strength in US adults: A cross-sectional study.Medicine · 2025Article
- Association of Handgrip Strength with Diabetes, Hypertension, and Comorbidities in a Korean Population: A Large-Scale Cross-Sectional Study.Journal of clinical medicine · 2025Article
- Lockdown influence on diet and physical activity of seniors; has it weight consequences?Central European journal of public health · 2024Article
- Article
- Factors associated with body mass index in a cohort of older adults: Structural equation modeling analysis.PloS one · 2024Article
- Increased BMI and late-life mobility dysfunction; overlap of genetic effects in brain regions.International journal of obesity (2005) · 2023Article
- Exploring the interplay between mechanisms of neuroplasticity and cardiovascular health in aging adults: A multiple linear regression analysis study.Autonomic neuroscience : basic & clinical · 2022Article
- Model Testing of the Factors That Influence Performance of Function Focused Care and Function Among Assisted Living Residents.Journal of applied gerontology : the official journal of the Southern Gerontological Society · 2022Article
- A Synergistic Association Between Inflammation, Malnutrition, and Mortality in Patients With Diabetics.Frontiers in nutrition · 2022Article
- The Relationships of Fibrinogen and C-Reactive Protein With Gait Performance: A 20-Year Longitudinal Study.Frontiers in aging neuroscience · 2022Article
- Associations between Circulating Inflammatory Biomarkers and Indicators of Muscle Health in Older Men and Women.Journal of clinical medicine · 2021Article
- Associations Between Measures of Physical Activity and Muscle Size and Strength: A Systematic Review.Archives of rehabilitation research and clinical translation · 2021Review
- Poor health-related physical fitness performance increases the overweight and obesity risk in older adults from Taiwan.BMC geriatrics · 2021Article
- Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure.Scientific reports · 2021Article
- Obesity, Even in the Metabolically Healthy, Increases the Risk of Poor Physical Performance: A Cross-Sectional Study of Older People in a Chinese Community.Clinical interventions in aging · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundInflammation is implicated in functional decline and the development of disability in aging. This study aimed to investigate the association of inflammation with physical function and muscle strength in older adults with obesity and increased cardiometabolic risk.
designIn baseline assessments from the CROSSROADS randomized controlled trial, serum interleukin-6 (IL-6), tumor necrosis factor-α (TNFα) and C-reactive protein (hs-CRP) were assayed in 163 older adults (37% males, 24% African American, BMI 34±3, age 70±5yrs) with hypertension, dyslipidemia and/or diabetes. Physical function was assessed by six-minute walk test (6MWT), chair sit-and-reach (CSR), hand-grip and knee-extension strength; specific-strength as muscle strength/mass ratio. Analyses included ANCOVA and multiple linear regression adjusted for thigh skeletal muscle (MRI), arm lean mass (DXA) and moderate-to-vigorous intensity physical activity (MVPA; accelerometry).
resultsHigher hs-CRP (p<0.01) and IL-6 (p=0.07) were associated with lower 6MWT and CSR, respectively. A composite inflammation score combining all 3 inflammatory markers showed the strongest inverse association with 6MWT (p<0.01). MVPA moderated associations such that amongst participants who engaged in low MVPA, 6MWT distances and CSR scores were significantly lower in those with high IL-6 and TNFα (p<0.05), respectively. In participants with high MVPA, higher hs-CRP (p<0.05) and TNFα (p=0.07) were associated with poorer upper-extremity specific-strength.
conclusionsChronic inflammation was associated with poorer physical function and specific strength in older adults with obesity and increased cardiometabolic risk. This association was strongest in participants with multiple elevated inflammatory markers. Physical activity levels below current recommendations mitigated the deleterious effects of inflammation on lower body mobility, underscoring the benefits of exercise for preserving physical function with age.
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Registered trials
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