ArticleOrganic & biomolecular chemistry2019
Photoaffinity probes for nematode pheromone receptor identification.
Article in Organic & biomolecular chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 9 citations in OpenAlex.
- Ascarosides and Symbiotic Bacteria of Entomopathogenic Nematodes Regulate Host Immune Response inInsects · 2024Article
- Transcriptomic profiling of sex-specific olfactory neurons reveals subset-specific receptor expression in Caenorhabditis elegans.Genetics · 2023Article
- Deep Interrogation of Metabolism Using a Pathway-Targeted Click-Chemistry Approach.Journal of the American Chemical Society · 2020Article
- Small molecule signals mediate social behaviors inJournal of neurogeneticsReview
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Identification of pheromone receptors plays a central role for uncovering signaling pathways that underlie chemical communication in animals. Here, we describe the synthesis and bioactivity of photoaffinity probes for the ascaroside ascr#8, a sex-pheromone of the model nematode, Caenorhabditis elegans. Structure-activity studies guided incorporation of alkyne- and diazirine-moieties and revealed that addition of functionality in the sidechain of ascr#8 was well tolerated, whereas modifications to the ascarylose moiety resulted in loss of biological activity. Our study will guide future probe design and provides a basis for pheromone receptor identification via photoaffinity labeling in C. elegans.
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Registered trials
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