Evidence map›Paper›PMID 31781544›Full record

ArticleFrontiers in chemistry2019

A Supramolecular Interaction of a Ruthenium Complex With Calf-Thymus DNA: A Ligand Binding Approach by NMR Spectroscopy.

Flávio Vinícius Crizóstomo Kock, Analu Rocha Costa, Katia Mara de Oliveira, Alzir Azevedo Batista, Antônio Gilberto Ferreira, Tiago Venâncio

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 8 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Flávio Vinícius Crizóstomo KockLaboratory of Nuclear Magnetic Resonance, Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil.
Analu Rocha CostaLaboratory of Structure and Reactivity of Inorganic Compounds, Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil.
Katia Mara de OliveiraLaboratory of Structure and Reactivity of Inorganic Compounds, Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil.
Alzir Azevedo BatistaLaboratory of Structure and Reactivity of Inorganic Compounds, Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil.
Antônio Gilberto FerreiraLaboratory of Nuclear Magnetic Resonance, Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil.
Tiago VenâncioLaboratory of Nuclear Magnetic Resonance, Department of Chemistry, Federal University of São Carlos, São Carlos, Brazil.
Universidade Federal de São Carlos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lawsone itself exhibits interesting biological activities, and its complexation with a metal center can improve the potency. In this context a cytotoxic Ru-complex, [Ru(law)(dppb)(bipy)] (law = lawsone, dppb = 1,4-bis(diphenylphosphino)butane and bipy = 2,2'-bipyridine), named as CBLAU, was prepared as reported. In this work, NMR binding-target studies were performed to bring to light the most accessible interaction sites of this Ru-complex toward Calf-Thymus DNA (CT-DNA, used as a model), in a similar approach used for other metallic complexes with anti-cancer activity, such as cisplatin and carboplatin. Advanced and robust NMR binding-target studies, among them Saturation Transfer Difference (STD)-NMR and longitudinal relaxometry (T

Indexed as

anti-cancerbinding interactionsCT-DNAlawsoneNMRruthenium complex

Identifiers

PMID31781544
PMCPMC6857657
OpenAlexW2982751995

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.