Evidence map›Paper›PMID 31781321›Full record

ArticleOxidative medicine and cellular longevity2019

A Solid Dispersion of Quercetin Shows Enhanced Nrf2 Activation and Protective Effects against Oxidative Injury in a Mouse Model of Dry Age-Related Macular Degeneration.

Yan Shao, Haitao Yu, Yan Yang, Min Li, Li Hang, Xinrong Xu

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. Bioactive compound combinations fromFrontiers in pharmacology · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Frontiers in pharmacology · 2025
    Review
  12. Beneficial Effects ofNutrients · 2024
    Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Yan ShaoDepartment of Ophthalmology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.ORCID https://orcid.org/0000-0003-1188-0237
Haitao YuSchool of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Yan YangDepartment of Ophthalmology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210017, China.
Min LiDepartment of Ophthalmology, Liyang Branch of the Affiliated Hospital of Nanjing University of Chinese Medicine, Liyang 213300, China.
Li HangDepartment of Ophthalmology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.
Xinrong XuDepartment of Ophthalmology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China.ORCID https://orcid.org/0000-0003-2047-7298
Nanjing University of Chinese Medicine · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) represents a major reason for blindness in the elderly population. Oxidative stress is a predominant factor in the pathology of AMD. We previously evaluated the effects of phospholipid complex of quercetin (Q-PC) on oxidative injury in ARPE-19 cells, but the underlying mechanisms are not fully understood. Herein, the solid dispersion of quercetin-PC (Q-SD) was prepared with solubility being 235.54

Indexed as

AnimalsEye ProteinsFemaleGene Expression RegulationGene Expression Regulation, EnzymologicMacular DegenerationMiceMice, KnockoutNF-E2-Related Factor 2Oxidation-ReductionOxidoreductasesQuercetinRatsRats, Sprague-DawleyReactive Oxygen SpeciesEye ProteinsNfe2l2 protein, mouseNF-E2-Related Factor 2OxidoreductasesQuercetinReactive Oxygen Species

Identifiers

PMID31781321
PMCPMC6875405
OpenAlexW2985613529

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.