ReviewEvidence-based complementary and alternative medicine : eCAM2019
Toxicity Assessment of Herbal Medicine Using Zebrafish Embryos: A Systematic Review.
Review in Evidence-based complementary and alternative medicine : eCAM, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
25 citing papers in PubMed.
- Article
- Article
- Integrative use of murine and zebrafish models for acute toxicity observation of ethanolic extract of Ocimum sanctum Linn.Open veterinary journal · 2026Article
- Developmental toxicity and physicochemical characterization of cisplatin-loaded ginger oil nanoemulsion in casper zebrafish.Frontiers in toxicology · 2026Article
- The zebrafish model: a versatile platform for uncovering the therapeutic potential of phytochemicals in liver diseases.Frontiers in pharmacology · 2026Review
- A novel bacterial symbiont in the seaweedFrontiers in microbiology · 2026Article
- Effects ofMolecules (Basel, Switzerland) · 2025Article
- Unveiling the toxicological mechanisms and biological impacts of copper sulfide nanoparticles on zebrafish.Nanomedicine (London, England) · 2025Article
- Leaf and fruit extracts ofToxicology reports · 2025Article
- Larvicidal Activity of Extracts from theInsects · 2025Article
- Toxicological and Sedative Effects of Chipilin (ACS omega · 2024Article
- Evaluation of the Anti-Inflammatory and Antioxidant Potential ofAnimals : an open access journal from MDPI · 2024Article
- Essential Oils Produce Developmental Toxicity in Zebrafish Embryos and Cause Behavior Changes in Zebrafish Larvae.Biomedicines · 2023Article
- Phytochemical analysis, antioxidant, α-glucosidase inhibitory activity, and toxicity evaluation of Orthosiphon stamineus leaf extract.Scientific reports · 2023Article
- Article
- A New Hypoglycemic Prenylated Indole AlkaloidInternational journal of molecular sciences · 2023Article
- Chemical Characterization, Antibacterial Activity, and Embryo Acute Toxicity ofFoods (Basel, Switzerland) · 2022Article
- Toxicity Mitigation of Textile Dye Reactive Blue 4 by Hairy Roots ofBioMed research international · 2022Article
- In Vitro and In Vivo Toxicity Evaluation of Natural Products with Potential Applications as Biopesticides.Toxins · 2021Article
- Preliminary Insight of Pyrrolylated-Chalcones as New Anti-Methicillin-ResistantMolecules (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Herbal remedies have been practiced by humans over centuries and therefore possess time-proven safety. However, it is imperative to evaluate the toxic effects of herbal medicine to confirm their safety, particularly when developing therapeutic leads. Use of laboratory animals such as rats, mice, and rabbits was considered as gold standard in herbal toxicity assessments. However, in the last few decades, the ethical consideration of using higher vertebrates for toxicity testing has become more contentious. Thus, possible alternative models entailing lower vertebrates such as zebrafish were introduced. The zebrafish embryotoxicity model is at the forefront of toxicology assessment due to the transparent nature of embryos, low cost, short cycle, higher fecundity, and genetic redundancy to the humans. Recently, its application has been extended to herbal toxicology. The present review intends to provide a comprehensive assembly of studies that applied the zebrafish embryo model for the assessment of herbal toxicity. A systematic literature survey was carried out in popular scientific databases. The literature search identified a total of 1014 articles in PubMed = 12, Scopus SciVerse® = 623, and Google Scholar = 1000. After screening, 25 articles were included in this review, and they were categorized into three groups in which the zebrafish embryotoxicity assay has been applied to investigate the toxicity of (1) polyherbal formulae/medical prescription (2 full texts), (2) crude extracts (12 full texts), and (3) phytocompounds/isolated constituents (11 full texts). These studies have investigated the toxicity of 6 polyherbal formulae, 16 crude extracts, and more than 30 phytocompounds/isolated constituents using the zebrafish embryotoxicity model. Moreover, this model has explicated the teratogenic effects and specific organ toxicities such as the kidney, heart, and liver. Furthermore, in some studies, the molecular mechanisms underlying the toxicity of herbal medicine have been elucidated. This comprehensive collection of scientific data solidifies the zebrafish embryo model as an effective model system for studying toxicological effects of a broad spectrum of herbal remedies. Henceforth, it provides a novel insight into the toxicity assessment of herbal medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.