Evidence map›Paper›PMID 31781230›Full record

ArticleObstetrics and gynecology international2019

Succinate-Based Dietary Supplement for Menopausal Symptoms: A Pooled Analysis of Two Identical Randomized, Double-Blind, Placebo-Controlled Clinical Trials.

Viktor E Radzinsky, Yulia Uspenskaya, Lee P Shulman, Irina V Kuznetsova

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Obstetrics and gynecology international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Paternal Zn-deficiency abolishes metabolic effects in offspring induced by diet type.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Viktor E RadzinskyDepartment of Obstetrics and Gynecology with a Course of Perinatology, The Peoples' Friendship University of Russia Medical Institute, Mikluho-Maklaya St. 8, 117198 Moscow, Russia.
Yulia UspenskayaDepartment of Obstetrics and Gynecology, The I.M. Sechenov First Moscow State Medical University, Elanskogo Str. 2, bld. 1, Moscow, Russia.
Lee P ShulmanDepartment of Obstetrics and Gynecology, Feinberg School of Medicine of Northwestern University, 250 East Superior Street, Room 05-2174, Chicago, USA.ORCID https://orcid.org/0000-0002-4781-0866
Irina V KuznetsovaDepartment of Obstetrics and Gynecology, The I.M. Sechenov First Moscow State Medical University, Elanskogo Str. 2, bld. 1, Moscow, Russia.
Sechenov University · RUNorthwestern University · USPeoples' Friendship University of Russia · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo evaluate the efficacy of a succinate-based dietary supplement (SBDS; Amberen) in symptomatic menopausal women using a larger sample size derived by pooling data from two identical trials.

methodsRaw

resultsSBDS use resulted in significant improvements in several endpoints including alleviation of 16 of 21 menopausal symptoms (

conclusionsThe pooled analysis reaffirms the outcomes from the individual trials. A nonhormonal, succinate-based dietary supplement is shown to relieve menopausal symptoms when compared to a placebo regimen in a randomized, double-blinded clinical trial.

Identifiers

PMID31781230
PMCPMC6875258
OpenAlexW2985200821

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.