Evidence map›Paper›PMID 31781121›Full record

ArticleFrontiers in immunology2019

Thioredoxin-Interacting Protein Promotes Phagosomal Acidification Upon Exposure to

Sung-Jin Yoon, Dong Hyun Jo, Seung-Ho Park, Jun-Young Park, Yoo-Kyung Lee, Moo-Seung Lee, Jeong-Ki Min, Haiyoung Jung, Tae-Don Kim, Suk Ran Yoon and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 1 country.

Sung-Jin YoonEnvironmental Disease Research Center, Daejeon, South Korea.
Dong Hyun JoFight Against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Seung-Ho ParkEnvironmental Disease Research Center, Daejeon, South Korea.
Jun-Young ParkEnvironmental Disease Research Center, Daejeon, South Korea.
Yoo-Kyung LeeEnvironmental Disease Research Center, Daejeon, South Korea.
Moo-Seung LeeEnvironmental Disease Research Center, Daejeon, South Korea.
Jeong-Ki MinBiotherapeutics Translational Research Center, Daejeon, South Korea.
Haiyoung JungImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.
Tae-Don KimImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.
Suk Ran YoonImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.
Su Wol ChungSchool of Biological Sciences, College of Natural Sciences, University of Ulsan, Ulsan, South Korea.
Jeong Hun KimFight Against Angiogenesis-Related Blindness (FARB) Laboratory, Clinical Research Institute, Seoul National University Hospital, Seoul, South Korea.
Inpyo ChoiImmunotherapy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, South Korea.
Young-Jun ParkEnvironmental Disease Research Center, Daejeon, South Korea.
Korea Research Institute of Bioscience and Biotechnology · KRSeoul National University · KRSeoul National University Hospital · KRUniversity of Ulsan · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In host defense, it is crucial to maintain the acidity of the macrophage phagosome for effective bacterial clearance. However, the mechanisms governing phagosomal acidification upon exposure to gram-negative bacteria have not been fully elucidated. In this study, we demonstrate that in macrophages exposed to

Indexed as

AnimalsCarrier ProteinsCaspase 1Enzyme ActivationEscherichia coliEscherichia coli InfectionsHydrogen-Ion ConcentrationInflammasomesMacrophagesMiceMice, Inbred C57BLMice, KnockoutNADPH OxidasesPhagosomesThioredoxinsCarrier ProteinsCasp1 protein, mouseCaspase 1InflammasomesNADPH OxidasesThioredoxinsTxnip protein, mousecaspaseEscherichia colimacrophagephagosomethioredoxin-interacting protein

Identifiers

PMID31781121
PMCPMC6861186
OpenAlexW2985506286

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.