ArticleFrontiers in immunology2019
Dynamic Evolution of Antimicrobial Peptides Underscores Trade-Offs Between Immunity and Ecological Fitness.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
- Review
- Article
- Functional characterization of Paillotin: an immune peptide regulated by the Immune deficiency (Imd) pathway with pathogen-specific roles inProceedings. Biological sciences · 2025Article
- Effects of population density on immunity and reproduction in bean beetles Callosobruchus maculatus.Scientific reports · 2025Article
- Article
- Genetic Variation and Gene Expression of the Antimicrobial Peptide Macins in Asian Buffalo Leech (Biology · 2025Article
- Characterization of avian β-defensin genes in Galliformes reveals widespread evolutionary diversification and distinct evolutionary relationships with infection risk.BMC genomics · 2025Article
- Latitudinal Clines in Climate and Sleep Patterns Shape Disease Outcomes inEcology and evolution · 2025Article
- Evolution of resistance and disease tolerance mechanisms to oral bacterial infection inOpen biology · 2025Article
- Dissecting transmission to understand parasite evolution.PLoS pathogens · 2025Review
- Paving the way for new antimicrobial peptides through molecular de-extinction.Microbial cell (Graz, Austria) · 2025Article
- Proline-Rich Antimicrobial Peptides from Invertebrates.Molecules (Basel, Switzerland) · 2024Review
- Prokaryotic Expression and Functional Verification of Antimicrobial Peptide LRInternational journal of molecular sciences · 2024Article
- A novel family of defensin-like peptides from Hermetia illucens with antibacterial properties.BMC microbiology · 2024Article
- Cereal weevils' antimicrobial peptides: at the crosstalk between development, endosymbiosis and immune response.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- Novel technologies uncover novel 'anti'-microbial peptides inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Article
- A single amino acid polymorphism in natural Metchnikowin alleles of Drosophila results in systemic immunity and life history tradeoffs.PLoS genetics · 2024Article
- Multi-omics resources for the Australian southern stuttering frog (Mixophyes australis) reveal assorted antimicrobial peptides.Scientific reports · 2024Article
- Evolution of five environmentally responsive gene families in a pine-feeding sawfly,Ecology and evolution · 2023Article
- Natural selection has driven the recurrent loss of an immunity gene that protectsProceedings of the National Academy of Sciences of the United States of America · 2023Article
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Authors and funding
3 authors.
Funding
Abstract
There is a developing interest in how immune genes may function in other physiological roles, and how traditionally non-immune peptides may, in fact, be active in immune contexts. In the absence of infection, the induction of the immune response is costly, and there are well-characterized trade-offs between immune defense and fitness. The agents behind these fitness costs are less understood. Here we implicate antimicrobial peptides (AMPs) as particularly costly effectors of immunity using an evolutionary framework. We describe the independent loss of AMPs in multiple lineages of Diptera (true flies), tying these observations back to life history. We then focus on the intriguing case of the glycine-rich AMP,
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