ArticleFrontiers in immunology2019
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05468866 (The Expression of Immune Checkpoint CD28 rs1980422-related Single-nucleotide Polymorphisms in the Primary Immune Thrombocytopenia), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Expression of Immune Checkpoint CD28 rs1980422-related Single-nucleotide Polymorphisms in the Primary Immune Thrombocytopenia
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Association ofFrontiers in immunology · 2021Pooled it
- Targeting FOXP3 and Regulatory T Cells in Systemic Lupus Erythematosus: Emerging Therapeutic Strategies and Clinical Prospects.Journal of cellular biochemistry · 2026Review
- Differential methylation of immune-related genes and its clinical significance in systemic lupus erythematosus: insights from TET2, FOXP3, and IFI44L genes.Molecular biology reports · 2026Article
- Bridging B-cell autoimmunity and oncology: the PD-1/PD-L1 paradox in systemic lupus erythematosus.Frontiers in immunology · 2026Review
- Bayesian Effect Size Ranking to Prioritise Genetic Risk Variants in Common Diseases for Follow-Up Studies.Genetic epidemiology · 2025Article
- Exploring the Role of PD-1 in the Autoimmune Response: Insights into Its Implication in Systemic Lupus Erythematosus.International journal of molecular sciences · 2024Review
- Regulation of T Cell Signaling and Immune Responses by PTPN22.Molecular and cellular biology · 2024Review
- Helios as a Potential Biomarker in Systemic Lupus Erythematosus and New Therapies Based on Immunosuppressive Cells.International journal of molecular sciences · 2023Review
- The effect of PD-1/PD-L1 signaling axis on the interaction between CD19Advances in rheumatology (London, England) · 2023Article
- Transcriptome sequencing reveals novel molecular features of SLE severity.Frontiers in genetics · 2023Article
- The effect of combining PD-1 agonist and low-dose Interleukin-2 on treating systemic lupus erythematosus.Frontiers in immunology · 2023Review
- Low-dose IL-2 reduces IL-21Nature communications · 2022Article
- Helios Expression Is Downregulated on CD8Frontiers in immunology · 2022Article
- Improvement of Lipoplexes With a Sialic Acid Mimetic to Target the C1858TFrontiers in immunology · 2022Article
- Non-HLA Gene Polymorphisms in the Pathogenesis of Type 1 Diabetes: Phase and Endotype Specific Effects.Frontiers in immunology · 2022Article
- HLA and Non-HLA gene polymorphisms in autoimmune hepatitis patients of North Indian adults.Frontiers in immunology · 2022Article
- Preparation and In Vitro Evaluation of RITUXfab-Decorated Lipoplexes to Improve Delivery of siRNA Targeting C1858T PTPN22 Variant in B Lymphocytes.International journal of molecular sciences · 2021Article
- Overexpression of theJournal of immunology (Baltimore, Md. : 1950) · 2021Article
- Spatial Regulation of T-Cell Signaling by Programmed Death-Ligand 1 on Wireframe DNA Origami Flat Sheets.ACS nano · 2021Article
- Genetic Susceptibility to Joint Occurrence of Polycystic Ovary Syndrome and Hashimoto's Thyroiditis: How Far Is Our Understanding?Frontiers in immunology · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 5 institutions in 2 countries.
Ricardo C FerreiraJDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Xaquin Castro DopicoCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
João J OliveiraCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Daniel B RainbowJDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Jennie H YangDepartment of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom.
Dominik TrzupekJDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Sarah A ToddCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Mhairi McNeillCambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom.
Maristella SteriIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.
Valeria OrrùIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.
Edoardo FiorilloIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.
Daniel J M CrouchJDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Marcin L PekalskiJDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
Francesco CuccaIstituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche (CNR), Rome, Italy.
Tim I TreeDepartment of Immunobiology, NIHR Biomedical Research Centre, King's College London, London, United Kingdom.
Tim J VyseDepartment of Medical & Molecular Genetics, King's College London, Guy's Hospital, London, United Kingdom.
Linda S WickerJDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
John A ToddJDRF/Wellcome Diabetes and Inflammation Laboratory, Nuffield Department of Medicine, Wellcome Centre for Human Genetics, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, United Kingdom.
University of Oxford · GBInstitute of Genetic and Biomedical Research · ITUniversity of Cambridge · GBKing's College London · GBCentre for Human Genetics · GB
Funding
Wellcome Trust
Abstract
In systemic lupus erythematosus (SLE), perturbed immunoregulation underpins a pathogenic imbalance between regulatory and effector CD4
Indexed as
AdultAgedAged, 80 and overAllelesAutoimmunityFemaleForkhead Transcription FactorsHumansInterleukin-2Lupus Erythematosus, SystemicMaleMiddle AgedProgrammed Cell Death 1 ReceptorProtein Tyrosine Phosphatase, Non-Receptor Type 22RiskT-Lymphocytes, RegulatoryForkhead Transcription FactorsFOXP3 protein, humanIL2 protein, humanInterleukin-2PDCD1 protein, humanProgrammed Cell Death 1 ReceptorProtein Tyrosine Phosphatase, Non-Receptor Type 22PTPN22 protein, humanautoimmunityFOXP3immunotherapyPD-1PTPN22 Arg620Trpregulatory T cells (Tregs)systemic lupus erythematosus (SLE)type I interferon
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT05468866ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.