Evidence map›Paper›PMID 31781099›Full record

ArticleFrontiers in immunology2019

Siglec-G Deficiency Ameliorates Hyper-Inflammation and Immune Collapse in Sepsis via Regulating Src Activation.

Wenqian Li, Yinjiao Li, Kewei Qin, Boxiang Du, Tianliang Li, Hongbin Yuan, Chaofeng Han, Yan Luo

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
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  4. Intragraft B cell differentiation during the development of tolerance to kidney allografts is associated with a regulatory B cell signature revealed by single cell transcriptomics.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Wenqian LiDepartment of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Yinjiao LiDepartment of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Kewei QinCentral Laboratory, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China.
Boxiang DuThe Second Affiliated Hospital of Nantong University, Nantong, China.
Tianliang LiNational Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China.
Hongbin YuanDepartment of Anesthesiology, Changzheng Hospital, Second Military Medical University, Shanghai, China.
Chaofeng HanNational Key Laboratory of Medical Immunology, Institute of Immunology, Second Military Medical University, Shanghai, China.
Yan LuoDepartment of Anesthesiology, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Second Military Medical University · CNRuijin Hospital · CNChinese PLA General Hospital · CNNantong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hyper-inflammation during acute phase and sequential hypo-inflammation during immunosuppressive phase in macrophages/monocytes lead to multiorgan failure syndrome and immune collapse of sepsis, in which toll-like receptor (TLR)-triggered inflammatory responses play a major role. Here, we reported that

Indexed as

AnimalsCytokinesEnzyme ActivationHypoxia-Inducible Factor 1, alpha SubunitInflammationInterleukin-10LectinsMacrophagesMiceMice, Inbred C57BLNF-kappa BReceptors, Antigen, B-CellSepsisSH2 Domain-Containing Protein Tyrosine PhosphatasesSialic Acid Binding Immunoglobulin-like LectinsSignal TransductionCytokinesHypoxia-Inducible Factor 1, alpha SubunitInterleukin-10LectinsNF-kappa BReceptors, Antigen, B-CellSH2 Domain-Containing Protein Tyrosine PhosphatasesSialic Acid Binding Immunoglobulin-like LectinsSiglecg protein, mousesrc-Family KinasesStat3 protein, mouseSTAT3 Transcription FactorToll-Like Receptorsanti-inflammatory cytokinepro-inflammatory cytokinessepsisSiglec-GSrcSrc homology region 2 domain-containing phosphatase-1

Identifiers

PMID31781099
PMCPMC6859834
OpenAlexW2984251773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.