Evidence map›Paper›PMID 31781060›Full record

ArticleFrontiers in microbiology2019

Constructing and Characterizing Bacteriophage Libraries for Phage Therapy of Human Infections.

Shelley B Gibson, Sabrina I Green, Carmen Gu Liu, Keiko C Salazar, Justin R Clark, Austen L Terwilliger, Heidi B Kaplan, Anthony W Maresso, Barbara W Trautner, Robert F Ramig

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Discovery and characterization of a novelPHAGE (New Rochelle, N.Y.) · 2026
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Phage-induced protection against lethal bacterial reinfection.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  14. Isolation and Genomic Analysis ofAntibiotics (Basel, Switzerland) · 2025
    Article
  15. Optimizing phage therapy for carbapenem-resistantAntimicrobial agents and chemotherapy · 2025
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Challenges and opportunities of phage therapy forApplied and environmental microbiology · 2024
    Review

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shelley B GibsonDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Sabrina I GreenDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Carmen Gu LiuDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Keiko C SalazarDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Justin R ClarkDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Austen L TerwilligerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Heidi B KaplanDepartment of Microbiology and Molecular Genetics, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX, United States.
Anthony W MaressoDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Barbara W TrautnerDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.
Robert F RamigDepartment of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX, United States.

Funding

Bacteriophage to treat UTI caused by multidrug-resistant P. aeruginosaR21AI121545 · NIAID · BAYLOR COLLEGE OF MEDICINE · PI RAMIG, ROBERT FRANKLIN · 2016 to 2017
$436k
Bacteriophage to treat multidrug‐resistant UTI in Persons with Spinal Cord InjuryI01RX002595 · VA · MICHAEL E DEBAKEY VA MEDICAL CENTER · PI TRAUTNER, BARBARA WELLS · 2019 to 2023
–
NIAID NIH HHS R21 AI121545RRD VA I01 RX002595
6 · The paper itself

Abstract

Phage therapy requires libraries of well-characterized phages. Here we describe the generation of phage libraries for three target species:

Indexed as

host rangehuman infectionkilling spectrumphage characteristicsphage librariesphage therapy

Identifiers

PMID31781060
PMCPMC6861333

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.