Evidence map›Paper›PMID 31780959›Full record

ReviewFrontiers in psychiatry2019

Executive Function in Autism Spectrum Disorder: History, Theoretical Models, Empirical Findings, and Potential as an Endophenotype.

Eleni A Demetriou, Marilena M DeMayo, Adam J Guastella

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 110 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 8 pooled it
11.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 8 syntheses or guidelines pooled it, 245 citations in OpenAlex.

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  11. Article
  12. On markers of linguistic impairment in autism and their implementation.Journal of neural transmission (Vienna, Austria : 1996) · 2026
    Review
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  18. Bilingualism Enhances Metalinguistic Awareness in Autism: Extending the Two-Dimensional Grammaticality Judgment Task.Autism research : official journal of the International Society for Autism Research · 2026
    Article
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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Eleni A DemetriouAutism Clinic for Translational Research, Brain and Mind Centre, Faculty of Medicine and Health, Children's Hospital Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.
Marilena M DeMayoAutism Clinic for Translational Research, Brain and Mind Centre, Faculty of Medicine and Health, Children's Hospital Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.
Adam J GuastellaAutism Clinic for Translational Research, Brain and Mind Centre, Faculty of Medicine and Health, Children's Hospital Westmead Clinical School, University of Sydney, Sydney, NSW, Australia.
Children's Hospital at Westmead · AUUniversity of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This review presents an outline of executive function (EF) and its application to autism spectrum disorder (ASD). The development of the EF construct, theoretical models of EF, and limitations in the study of EF are outlined. The potential of EF as a cognitive endophenotype for ASD is reviewed, and the Research Domain Criteria (RDoC) framework is discussed for researching EF in ASD given the multifaceted factors that influence EF performance. A number of executive-focused cognitive models have been proposed to explain the symptom clusters observed in ASD. Empirical studies suggest a broad impairment in EF, although there is significant inter-individual variability in EF performance. The observed heterogeneity of EF performance is considered a limiting factor in establishing EF as a cognitive endophenotype in ASD. We propose, however, that this variability in EF performance presents an opportunity for subtyping within the spectrum that can contribute to targeted diagnostic and intervention strategies. Enhanced understanding of the neurobiological basis that underpins EF performance, such as the excitation/inhibition hypothesis, will likely be important. Application of the RDoC framework could provide clarity on the nature of EF impairment in ASD with potential for greater understanding of, and improved interventions for, this disorder.

Indexed as

autism spectrum disorderendophenotypeexcitation/inhibitionexecutive functionGABAneurobiology

Identifiers

PMID31780959
PMCPMC6859507
OpenAlexW2987470906

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.