ArticleFrontiers in systems neuroscience2019
Acetylcholine Mediates Dynamic Switching Between Information Coding Schemes in Neuronal Networks.
Article in Frontiers in systems neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Adjuvant effects of vagus nerve stimulation on post-stroke rehabilitation: a systematic review and meta-analysis.BMJ open · 2025Pooled it
- Acetylcholine enhances deviance detection in Hodgkin-Huxley neuronal networks.Cognitive neurodynamics · 2026Article
- Awake alpha bursting emerges as the dynamic working state in a lateral geniculate thalamocortical cell model.PLoS computational biology · 2026Article
- Dynamic cholinergic signaling differentially desynchronizes cortical microcircuits dependent on modulation rate and network connectivity.PLoS computational biology · 2026Article
- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- The tuning of tuning: How adaptation influences single cell information transfer.PLoS computational biology · 2024Article
- Acetylcholine facilitates localized synaptic potentiation and location specific feature binding.Frontiers in neural circuits · 2023Article
- Modeling cortical synaptic effects of anesthesia and their cholinergic reversal.PLoS computational biology · 2022Article
- Heterogeneous mechanisms for synchronization of networks of resonant neurons under different E/I balance regimes.Frontiers in network physiology · 2022Article
- Acetylcholine-gated current translates wake neuronal firing rate information into a spike timing-based code in Non-REM sleep, stabilizing neural network dynamics during memory consolidation.PLoS computational biology · 2021Article
- Theta-gamma coupling emerges from spatially heterogeneous cholinergic neuromodulation.PLoS computational biology · 2021Article
- Slowly activating outward membrane currents generate input-output sub-harmonic cross frequency coupling in neurons.Journal of theoretical biology · 2021Article
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5 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Rate coding and phase coding are the two major coding modes seen in the brain. For these two modes, network dynamics must either have a wide distribution of frequencies for rate coding, or a narrow one to achieve stability in phase dynamics for phase coding. Acetylcholine (ACh) is a potent regulator of neural excitability. Acting through the muscarinic receptor, ACh reduces the magnitude of the potassium M-current, a hyperpolarizing current that builds up as neurons fire. The M-current contributes to several excitability features of neurons, becoming a major player in facilitating the transition between Type 1 (integrator) and Type 2 (resonator) excitability. In this paper we argue that this transition enables a dynamic switch between rate coding and phase coding as levels of ACh release change. When a network is in a high ACh state variations in synaptic inputs will lead to a wider distribution of firing rates across the network and this distribution will reflect the network structure or pattern of external input to the network. When ACh is low, network frequencies become narrowly distributed and the structure of a network or pattern of external inputs will be represented through phase relationships between firing neurons. This work provides insights into how modulation of neuronal features influences network dynamics and information processing across brain states.
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