ArticleFrontiers in neuroscience2019
Heart Rate Variability Predicts Therapeutic Response to Metoprolol in Children With Postural Tachycardia Syndrome.
Article in Frontiers in neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Guidelines for the diagnosis and treatment of neurally mediated syncope in children and adolescents (revised 2024).World journal of pediatrics : WJP · 2024Guideline
- The Changes of T-Wave Amplitude and Tp-Te Interval in the Supine and Standing Electrocardiograms of Pediatric Postural Orthostatic Tachycardia Syndrome and Their Predictive Value for the Intervention Effect of Metoprolol.Journal of clinical medicine · 2026Article
- The body and the brain keep the score: a data-driven conceptual model linking trauma and postural tachycardia syndrome.Frontiers in psychology · 2026Review
- The role of 24-hour wearable sensors in early evaluation of adolescent orthostatic dysregulation.PCN reports : psychiatry and clinical neurosciences · 2025Article
- Comparative analysis of autonomic nervous system function in patients with postural orthostatic tachycardia syndrome versus a head-up tilt testing-negative cohort.IBRO neuroscience reports · 2025Article
- Amiodarone combined with metoprolol improves cardiac function in patients with coronary heart disease complicated by arrhythmia.American journal of translational research · 2025Article
- Predicting Therapeutic Efficacy of Pharmacological Treatments in Children with Postural Orthostatic Tachycardia Syndrome: A Mini-Review.Children (Basel, Switzerland) · 2023Review
- A predictive model of response to metoprolol in children and adolescents with postural tachycardia syndrome.World journal of pediatrics : WJP · 2023Article
- Poincaré plot can help predict the curative effect of metoprolol for pediatric postural orthostatic tachycardia syndrome.Frontiers in neuroscience · 2023Article
- Biomarkers and Hemodynamic Parameters in the Diagnosis and Treatment of Children with Postural Tachycardia Syndrome and Vasovagal Syncope.International journal of environmental research and public health · 2022Review
- Baroreflex sensitivity predicts therapeutic effects of metoprolol on pediatric postural orthostatic tachycardia syndrome.Frontiers in cardiovascular medicine · 2022Article
- Predictive Value of Heart Rate and Blood Pressure on the Prognosis of Postural Tachycardia Syndrome in Children.Frontiers in pediatrics · 2022Article
- Plasma human growth cytokines in children with vasovagal syncope.Frontiers in cardiovascular medicine · 2022Article
- Baseline left ventricular ejection fraction associated with symptom improvements in both children and adolescents with postural tachycardia syndrome under metoprolol therapy.Chinese medical journal · 2021Article
- Baseline Corrected QT Interval Dispersion Is Useful to Predict Effectiveness of Metoprolol on Pediatric Postural Tachycardia Syndrome.Frontiers in cardiovascular medicine · 2021Article
- Prognostic Value of Biomarkers in Children and Adolescents With Orthostatic Intolerance.Frontiers in pediatrics · 2021Review
- Impact of Comorbidities on the Prognosis of Pediatric Postural Tachycardia Syndrome.International journal of general medicine · 2021Article
- Vitamin D Deficiency in Children With Vasovagal Syncope Is Associated With Impaired Circadian Rhythm of Blood Pressure.Frontiers in neuroscience · 2021Article
- Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain-heart axis.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo improve the metoprolol therapeutic effectiveness, we aimed to explore whether baseline heart rate variability (HRV) indicators before metoprolol treatment were useful for predicting its efficacy for postural tachycardia syndrome (POTS).
methodsWe recruited 45 children with POTS who received metoprolol and 17 healthy controls. All children underwent a standing test or basic head-up tilt test and 24-h dynamic electrocardiography before treatment. After 3 months of metoprolol, therapeutic responsiveness was evaluated. The usefulness of baseline HRV parameters in predicting the effectiveness of metoprolol was studied and the long-term cumulative symptom rate was analyzed.
resultsThe baseline HRV frequency domain indicators for power, ultra-low frequency, very-low frequency, low frequency (LF), high frequency (HF), and total power (TP) as well as time domain indicators were significantly lower for responders than non-responders to metoprolol; however, low-frequency normalized units and LF/HF ratio were markedly greater for responders than non-responders. On series-parallel analysis, combined baseline triangular (TR) index ≤ 33.7 and standard deviation of all normal-to-normal intervals (SDNN) index ≤ 79.0 ms as cut-off values yielded sensitivity, specificity and accuracy of 85.3, 81.8, and 84.4%, respectively, to predict therapeutic responsiveness to metoprolol. On long-term follow-up, the cumulative symptom rate was significantly higher with TR index > 33.7 and SDNN index ≤ 79.0 ms, TR index ≤ 33.7 and SDNN index > 79.0 ms or TR index > 33.7 and SDNN index > 79.0 ms than TR index ≤ 33.7 and SDNN index ≤ 79.0 ms (
conclusionCombined TR index ≤ 33.7 and SDNN index ≤ 79.0 ms were useful preliminary measures to predict therapeutic response to metoprolol in pediatric POTS.
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