ArticleScientific reports2019
Apple B-box factors regulate light-responsive anthocyanin biosynthesis genes.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Functional characterization of StBBX19 and StBBX24 in UV-B-induced anthocyanin biosynthesis in pigmented potato.BMC plant biology · 2026Article
- MdBBX47, a B-box transcription factor directly and indirectly regulates ALA-induced anthocyanin accumulation in apple.BMC plant biology · 2026Article
- Mechanical Pruning Induces Distinct Metabolic Responses in Slender Spindle-Shaped Apple Orchards.Plants (Basel, Switzerland) · 2025Article
- Genome-Wide Identification of the Litchi BBX Gene Family and Analysis of Its Potential Role in Pericarp Coloring.International journal of molecular sciences · 2025Article
- Anthocyanin pathway in eggplant: genetic regulation and future directions for metabolic engineering.Molecular biology reports · 2025Review
- The light-responsive transcription factor SlBBX20 improves low-temperature resistance of Solanum lycopersicum by affecting photosynthetic capacity, antioxidant capacity, and osmotic adjustment.Plant cell reports · 2025Article
- Identification of the BBX gene family in blueberry at different chromosome ploidy levels and fruit development and response under stress.BMC genomics · 2025Article
- Increased genomic predictive ability in mango using GWAS-preselected variants and fixed-effect SNPs.Frontiers in plant science · 2025Article
- Molecular Functional and Transcriptome Analysis ofPlants (Basel, Switzerland) · 2024Article
- Genome-Wide Identification of B-Box Family Genes and Their Potential Roles in Seed Development under Shading Conditions in Rapeseed.Plants (Basel, Switzerland) · 2024Article
- Article
- Involvement of CONSTANS-like Proteins in Plant Flowering and Abiotic Stress Response.International journal of molecular sciences · 2023Review
- Light regulation of the biosynthesis of phenolics, terpenoids, and alkaloids in plants.Communications biology · 2023Review
- VvBBX44 and VvMYBA1 form a regulatory feedback loop to balance anthocyanin biosynthesis in grape.Horticulture research · 2023Article
- Comparative Transcriptome Analysis of Purple and Green Flowering Chinese Cabbage and Functional Analyses ofInternational journal of molecular sciences · 2023Article
- Transcriptomic approach to uncover dynamic events in the development of mid-season sunburn in apple fruit.G3 (Bethesda, Md.) · 2023Article
- FaMYB5 Interacts with FaBBX24 to Regulate Anthocyanin and Proanthocyanidin Biosynthesis in Strawberry (International journal of molecular sciences · 2023Article
- A natural promoter variation of SlBBX31 confers enhanced cold tolerance during tomato domestication.Plant biotechnology journal · 2023Article
- Molecular and Metabolic Insights into Anthocyanin Biosynthesis for Spot Formation onInternational journal of molecular sciences · 2023Article
- Multi-layered roles of BBX proteins in plant growth and development.Stress biology · 2023Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Environmentally-responsive genes can affect fruit red colour via the activation of MYB transcription factors. The apple B-box (BBX) gene, BBX33/CONSTANS-like 11 (COL11) has been reported to influence apple red-skin colour in a light- and temperature-dependent manner. To further understand the role of apple BBX genes, other members of the BBX family were examined for effects on colour regulation. Expression of 23 BBX genes in apple skin was analysed during fruit development. We investigated the diurnal rhythm of expression of the BBX genes, the anthocyanin biosynthetic genes and a MYB activator, MYB10. Transactivation assays on the MYB10 promoter, showed that BBX proteins 1, 17, 15, 35, 51, and 54 were able to directly function as activators. Using truncated versions of the MYB10 promoter, a key region was identified for activation by BBX1. BBX1 enhanced the activation of MYB10 and MdbHLH3 on the promoter of the anthocyanin biosynthetic gene DFR. In transformed apple lines, over-expression of BBX1 reduced internal ethylene content and altered both cyanidin concentration and associated gene expression. We propose that, along with environmental signals, the control of MYB10 expression by BBXs in 'Royal Gala' fruit involves the integration of the expression of multiple BBXs to regulate fruit colour.
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