ArticleScientific data2019
A database of high-resolution MS/MS spectra for lichen metabolites.
Article in Scientific data, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Lichen-Derived Bioactive Compounds in Diabetes and Cardiovascular Risk: Experimental Evidence, Mechanisms, and Translational Challenges.Biomedicines · 2026Review
- Hidden diversity and chemical variation within Parmelia saxatilis group (Lecanorales, lichenized Ascomycota) and description of a new species P. tobolewskiana.Scientific reports · 2026Article
- Identification of Secondary Metabolites from the LichenMolecules (Basel, Switzerland) · 2026Article
- Dereplicative Combination of HPLC/DAD/MS and 2D NMR to Identify Lichexanthone Isomers in Lichen Extracts.Phytochemical analysis : PCA · 2026Article
- Paired-omics-based exploration and characterization of biosynthetic diversity in lichenized fungi.Microbial genomics · 2025Article
- Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases.MedComm · 2025Review
- Metabolomics navigates natural variation in pathogen-induced secondary metabolism across soybean cultivar populations.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont.Environmental microbiology · 2025Article
- Elevational microhabitats influence some endolichenic traits of Umbilicaria aprina, an alpine lichen species.Scientific reports · 2025Article
- Capillary Electrophoresis Optimization for Metabolite Separation inInternational journal of molecular sciences · 2025Article
- Breaking into nature's secret medicine cabinet: lichens - a biochemical goldmine ready for discovery.The New phytologist · 2025Review
- ROASMI: accelerating small molecule identification by repurposing retention data.Journal of cheminformatics · 2025Article
- An expanded database of high-resolution MS/MS spectra for lichen-derived natural products.Scientific data · 2025Article
- Biological activities ofFrontiers in pharmacology · 2024Article
- Chemical Constituents Isolated from the Lichen Biome of Selected Species Native to North America.Progress in the chemistry of organic natural products · 2024Review
- Open access repository-scale propagated nearest neighbor suspect spectral library for untargeted metabolomics.Nature communications · 2023Article
- Cytotoxic, anti-proliferative, and apoptotic evaluation of Ramalina sinensis (Ascomycota, Lecanoromycetes), lichenized fungus on oral squamous cell carcinoma cell line; in-vitro study.BMC complementary medicine and therapies · 2023Article
- A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides.Metabolites · 2023Article
- Linking Lichen Metabolites to Genes: Emerging Concepts and Lessons from Molecular Biology and Metagenomics.Journal of fungi (Basel, Switzerland) · 2023Review
- Lichen Depsides and Tridepsides: Progress in Pharmacological Approaches.Journal of fungi (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While analytical techniques in natural products research massively shifted to liquid chromatography-mass spectrometry, lichen chemistry remains reliant on limited analytical methods, Thin Layer Chromatography being the gold standard. To meet the modern standards of metabolomics within lichenochemistry, we announce the publication of an open access MS/MS library with 250 metabolites, coined LDB for Lichen DataBase, providing a comprehensive coverage of lichen chemodiversity. These were donated by the Berlin Garden and Botanical Museum from the collection of Siegfried Huneck to be analyzed by LC-MS/MS. Spectra at individual collision energies were submitted to MetaboLights (https://www.ebi.ac.uk/metabolights/MTBLS999) while merged spectra were uploaded to the GNPS platform (CCMSLIB00004751209 to CCMSLIB00004751517). Technical validation was achieved by dereplicating three lichen extracts using a Molecular Networking approach, revealing the detection of eleven unique molecules that would have been missed without LDB implementation to the GNPS. From a chemist's viewpoint, this database should help streamlining the isolation of formerly unreported metabolites. From a taxonomist perspective, the LDB offers a versatile tool for the chemical profiling of newly reported species.
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