ArticleTranslational psychiatry2019
Childhood intelligence attenuates the association between biological ageing and health outcomes in later life.
Article in Translational psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Epigenetic Aging and Cognitive Performance in General and Psychiatric Populations: A Systematic Review and Narrative Synthesis.Biological psychiatry global open science · 2026Review
- Translational Geroscience Strategies for Delaying Multimorbidity.ACS pharmacology & translational science · 2026Review
- Personality and epigenetic aging: A multi-cohort and multi-clock study.Psychoneuroendocrinology · 2025Article
- A review of artificial intelligence-based brain age estimation and its applications for related diseases.Briefings in functional genomics · 2025Review
- Five years of change in adult twins: longitudinal changes of genetic and environmental influence on epigenetic clocks.BMC medicine · 2024Article
- Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study.Aging cell · 2024Article
- CheekAge, a next-generation epigenetic buccal clock, is predictive of mortality in human blood.Frontiers in aging · 2024Article
- Epigenetic age acceleration as a biomarker for impaired cognitive abilities in adulthood following early life adversity and psychiatric disorders.Neurobiology of stress · 2023Article
- Overlapping brain correlates of superior cognition among children at genetic risk for Alzheimer's disease and/or major depressive disorder.Scientific reports · 2023Article
- Epigenetic clocks and research implications of the lack of data on whom they have been developed: a review of reported and missing sociodemographic characteristics.Environmental epigenetics · 2023Review
- Brain aging differs with cognitive ability regardless of education.Scientific reports · 2022Article
- Aging biomarkers and the brain.Seminars in cell & developmental biology · 2021Review
- Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging.Medicine and science in sports and exercise · 2021Article
- Mitochondrial Functions, Cognition, and the Evolution of Intelligence: Reply to Commentaries and Moving Forward.Journal of Intelligence · 2020Article
- Epigenetic measures of ageing predict the prevalence and incidence of leading causes of death and disease burden.Clinical epigenetics · 2020Article
- The Importance of Childhood for Adult Health and Development-Study Protocol of the Zurich Longitudinal Studies.Frontiers in human neuroscience · 2020Article
Corrections and comments
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Authors and funding
11 authors.
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Abstract
The identification of biomarkers that discriminate individual ageing trajectories is a principal target of ageing research. Some of the most promising predictors of biological ageing have been developed using DNA methylation. One recent candidate, which tracks age-related phenotypes in addition to chronological age, is 'DNAm PhenoAge'. Here, we performed a phenome-wide association analysis of this biomarker in a cohort of older adults to assess its relationship with a comprehensive set of both historical, and contemporaneously-measured, phenotypes. Higher than expected DNAm PhenoAge compared with chronological age, known as epigenetic age acceleration, was found to associate with a number of blood, cognitive, physical fitness and lifestyle variables, and with mortality. Notably, DNAm PhenoAge, assessed at age 70, was associated with cognitive ability at age 11, and with educational attainment. Adjusting for age 11 cognitive ability attenuated the majority of the cross-sectional later-life associations between DNAm PhenoAge and health outcomes. These results highlight the importance of early life factors on healthy older ageing.
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