ArticlePsychoneuroendocrinology2020
The allopregnanolone to progesterone ratio across the menstrual cycle and in menopause.
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Article in Psychoneuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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0cells of the map it votes in
31citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- A dense-sampling investigation of interoceptive variation across the menstrual cycle: the Cyclic Hormones and Interoception with Repeated Profiling (CHIRP) Study.Brain, behavior, & immunity - health · 2026Article
- Exploring the Physiological Effects and Mechanisms of Gamma-Aminobutyric Acid in Food Systems.Foods (Basel, Switzerland) · 2026Review
- Effects of Micronized Progesterone in Menopausal Hormone Replacement Therapy on Sleep.The journal of obstetrics and gynaecology research · 2026Article
- The Impact of Estradiol Dynamics During the Menopause Transition on Depression Risk: A Narrative Review of Estradiol's Neurobiological Mechanisms.Biological psychiatry · 2026Review
- Ovarian hormones, hormonal contraceptives and reward processing.BJPsych advances · 2026Article
- Within-person associations between daily ovarian steroid levels and mood-related symptoms in ovulatory and anovulatory early adolescents.Psychoneuroendocrinology · 2026Article
- Plasma Allopregnanolone and Sex Hormone Responses to Stress Induction: Contributors to the Formation of Intrusive Memories.Neuropsychobiology · 2026Article
- Introducing the SAGE study: a multimodal protocol for testing a GABAergic mechanism of age-related episodic memory impairment across the sexes.BMJ neurology open · 2026Article
- Neuroactive steroid levels are elevated in the follicular phase and predict premenstrual depression and anxiety symptom severity in women with menstrually related mood disorder.Archives of women's mental health · 2025Article
- Medial preoptic area FoxO1 controls metabolic adaptation in a sexually dimorphic manner.bioRxiv : the preprint server for biology · 2025Article
- Menopause, Perimenopause, and Migraine: Understanding the Intersections and Implications for Treatment.Neurology and therapy · 2025Review
- Neurosteroids: a lifelong impact on brain health.Frontiers in behavioral neuroscience · 2025Review
- Premenstrual dysphoric disorder as a potential predisposing factor for Alzheimer's disease: a review.Frontiers in endocrinology · 2025Review
- The relationship between hormonal contraceptives, level of anxiety and emotional awareness: pilot project.Physiological research · 2024Article
- Age and sex effects of a validated LC-MS/MS method for the simultaneous quantification of testosterone, allopregnanolone, and its isomers in human serum.Scientific reports · 2024Article
- Early Life Trauma, Emotion Dysregulation and Hormonal Sensitivity Across Female Reproductive Life Events.Current psychiatry reports · 2024Review
- Acute, but not repeated, cocaine exposure alters allopregnanolone levels in the midbrain of male and female rats.Psychopharmacology · 2024Article
- The role of neurosteroids in posttraumatic stress disorder and alcohol use disorder: A review of 10 years of clinical literature and treatment implications.Frontiers in neuroendocrinology · 2024Review
- Progesterone Receptor Activation Regulates Sensory Sensitivity and Migraine Susceptibility.The journal of pain · 2024Article
- Testosterone and Prolactin Perturbations Possibly Associated with Reduced Levels of β-Arrestin1 in Mononuclear Leukocytes of Women with Premenstrual Dysphoric Disorder.International journal of molecular sciences · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors at 5 institutions in 1 country.
Allison KimballNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Laura E DichtelNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Maren B NyerDepression Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
David MischoulonDepression Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Lauren B FisherDepression Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Cristina CusinDepression Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Christina M DordingDepression Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Nhi-Ha TrinhDepression Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Albert YeungDepression Clinical and Research Program, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Melanie S HainesNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Joshua C SungNeuroendocrine Unit, Massachusetts General Hospital, Boston, MA, USA.
Graziano PinnaThe Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Ann M RasmussonNational Center for PTSD, Department of Veterans Affairs, VA Boston Healthcare System, and Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
Linda L CarpenterButler Hospital, Brown Department of Psychiatry and Human Behavior, Providence, RI, USA.
Maurizio FavaDepartment of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Anne KlibanskiNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.
Karen Klahr MillerNeuroendocrine Unit, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. Electronic address: KKMiller@mgh.harvard.edu.
Massachusetts General Hospital · USHarvard University · USProvidence College · USUniversity of Illinois Chicago · USVA Boston Healthcare System · US
Funding
Harvard Clinical and Translational Science CenterUL1TR001102 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2013 to 2017
$106.2MZD6416 Analgesic--Painful Distal Symmetrical PolyneuropaM01RR001066 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWN, EMERY N · 1985 to 2008
$37.4MTRAINING PROGRAM IN ENDOCRINOLOGY AND DIABETEST32DK007028 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Karen K Miller · 1986 to 2026
$18.5MGrowth Hormone and Cardiovascular DiseaseK24HL092902 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI MILLER, KAREN K · 2010 to 2019
$1.6MRelative Sarcopenia and Cardiometabolic Risk in Young Adults with ObesityK23DK115903 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI HAINES, MELANIE SCHORR · 2017 to 2021
$1.1MThe Growth Hormone and Insulin-like Growth Factor-1 Axis in Nonalcoholic Fatty Liver Disease and Nonalcoholic SteatohepatitisK23DK113220 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DICHTEL, LAURA ELISABETH · 2017 to 2021
$1.1M1/2-Collaborative Study: Testosterone Antidepressant Augmentation in WomenR34MH099315 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FAVA, MAURIZIO, MILLER, KAREN K · 2013 to 2015
$783k2/2 Collaborative Study: Testosterone Augmentation in WomenR34MH099310 · NIMH · BUTLER HOSPITAL (PROVIDENCE, RI) · PI CARPENTER, LINDA L · 2013 to 2015
$633kNCATS NIH HHS UL1 TR001102NCRR NIH HHS M01 RR001066NHLBI NIH HHS K24 HL092902NIDDK NIH HHS K23 DK113220NIDDK NIH HHS K23 DK115903NIDDK NIH HHS T32 DK007028NIMH NIH HHS R34 MH099310NIMH NIH HHS R34 MH099315
Abstract
The neuroactive steroid 3α-5α-tetrahydroprogesterone (allopregnanolone), a metabolite of progesterone, is a positive allosteric modulator of GABA
Indexed as
AdultAgedFemaleFollicular PhaseHumansLuteal PhaseMenopauseMiddle AgedPregnanoloneProgesteroneYoung AdultPregnanoloneProgesteroneAllopregnanoloneMenopauseMenstrual cycleNeuroactive steroids
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.