ArticleJACC. Heart failure2019
Impact of Age on Comorbidities and Outcomes in Heart Failure With Reduced Ejection Fraction.
Article in JACC. Heart failure, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00047437 (Heart Failure), which is not on this map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training (HF-ACTION)
Who cites it
28 citing papers in PubMed.
- Pulmonary artery pressure monitoring in chronic heart failure: effects across clinically relevant subgroups in the MONITOR-HF trial.European heart journal · 2024Trial
- Prevalence and prognosis of multimorbidity in heart failure with mildly reduced ejection fraction.Clinical research in cardiology : official journal of the German Cardiac Society · 2026Article
- The Impact of Risk Factors and Comorbidities on Heart Failure in the Aging Population.International journal of molecular sciences · 2026Review
- Trends and Characterization of Hospitalizations with Heart Failure in Italy Before and During the COVID-19 Pandemic.Healthcare (Basel, Switzerland) · 2026Article
- Predicting heart failure decompensation: focus on non-invasive monitoring.Cardiology journal · 2026Review
- Combination of the Fibrosis 4 Index and Carbohydrate Antigen 125 to Predict Morbidity and Mortality in Acute Heart Failure.Reviews in cardiovascular medicine · 2025Article
- B-type Natriuretic Peptide Changes and Left Ventricular Remodeling Dynamics in Heart Failure with Reduced Ejection Fraction.medRxiv : the preprint server for health sciences · 2025Article
- Copeptin, Routine Laboratory Parameters, and Ischemic Etiology of Heart Failure Predict Outcomes in Elderly Patients with Decompensated Heart Failure.Biomedicines · 2025Article
- Differential Associations of Cardiac, Pulmonary, Arterial, and Muscle Physiological Parameters and Biomarkers With the Incidence of HFpEF and HFrEF.JACC. Heart failure · 2025Article
- Observational
- Age-Related Outcomes in Patients Undergoing Coronary Angiography: In Which Subgroups Does Age Matter? Results from a Large-Scale Retrospective Registry.Journal of clinical medicine · 2025Article
- [Predicting Intensive Care Unit Mortality in Patients With Heart Failure Combined With Acute Kidney Injury Using an Interpretable Machine Learning Model: A Retrospective Cohort Study].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025Article
- B-type natriuretic peptide changes and left ventricular remodeling dynamics in heart failure with reduced ejection fraction.Frontiers in cardiovascular medicine · 2025Article
- Predicting in-hospital mortality in patients with heart failure combined with atrial fibrillation using stacking ensemble model: an analysis of the medical information mart for intensive care IV (MIMIC-IV).BMC medical informatics and decision making · 2024Article
- Depression in Cardiac Patients Is a Major Cardiovascular Event Risk Factor: A 12-Month Observational Study.Journal of clinical medicine · 2024Article
- Exploring the Association Between Heart Rate Control and Rehospitalization: A Real-World Analysis of Patients Hospitalized with Heart Failure with Reduced Ejection Fraction.Drugs - real world outcomes · 2024Article
- Cost-Utility Analysis of 3-Month Telemedical Intervention for Heart Failure Patients: A Preliminary Study from Poland.Healthcare (Basel, Switzerland) · 2024Article
- Impact of age on characteristics, performance measures and outcomes of inpatients for heart failure in Beijing, China.ESC heart failure · 2023Article
- The Influence of Body Mass Index on Clinical Interpretation of Established and Novel Biomarkers in Acute Heart Failure.Journal of cardiac failure · 2023Article
- Association of Depression and Anxiety with Cardiac Structural and Functional Characteristics in Heart Failure with Reduced and Mildly Reduced Ejection Fraction.Clinics and practice · 2023Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
objectivesThis study sought to determine whether age modifies the impact of key comorbidities on clinical outcomes for patients with heart failure with reduced ejection fraction (HFrEF).
backgroundComorbidities impact outcomes in HFrEF. However, the effect of age on the impact of comorbidities on prognosis is not clearly understood.
methodsCox proportional hazards models were used assessed interactions between age and comorbidities on the primary composite endpoint (all-cause mortality or hospitalization) and secondary endpoints in the HF-ACTION (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training) multicenter trial of 2,331 patients with HFrEF.
resultsAge did not significantly modify the effect of any comorbidity on the primary endpoint. However, age significantly modified the effect of body mass index (BMI) on all-cause mortality (interaction p = 0.02). Among patients ≥70 years of age, there was a U-shaped relationship between BMI and 1-year mortality, where BMI of 20 kg/m
conclusionsIn chronic HFrEF, age markedly altered the impact of BMI and depressive symptoms on all-cause mortality, with much higher risk in older patients, but was not as strong a predictor of mortality/hospitalizations as cumulative comorbidity score. (Heart Failure: A Controlled Trial Investigating Outcomes of Exercise Training [HF-ACTION]; NCT00047437).
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