ArticleGenome biology2019
547 transcriptomes from 44 brain areas reveal features of the aging brain in non-human primates.
Article in Genome biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Imaging Genomics Across Primate Species: Advancing Understanding of Neurological and Psychiatric Disorders.Neuroscience bulletin · 2026Review
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- Regional and aging-specific cellular architecture of non-human primate brains.Genome medicine · 2025Article
- A computational framework for detecting inter-tissue gene-expression coordination changes with aging.Scientific reports · 2025Article
- Dysregulation of astrocytic Aquaporin-1 in the brains of oldest-old rhesus macaques: the NIA caloric restriction study.GeroScience · 2025Article
- Single-neuron analysis of aging-associated changes in learning reveals impairments in transcriptional plasticity.Aging cell · 2024Article
- Integrated multi-omics analysis of brain aging in female nonhuman primates reveals altered signaling pathways relevant to age-related disorders.Neurobiology of aging · 2023Article
- SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B.Nature aging · 2023Article
- Multi-Omics Analysis Reveals Age-Related Microbial and Metabolite Alterations in Non-Human Primates.Microorganisms · 2023Article
- Integrative Omics Reveals Rapidly Evolving Regulatory Sequences Driving Primate Brain Evolution.Molecular biology and evolution · 2023Article
- Decoding hereditary spastic paraplegia pathogenicity through transcriptomic profiling.Zoological research · 2023Review
- Current advances in primate genomics: novel approaches for understanding evolution and disease.Nature reviews. Genetics · 2023Review
- Brain-wide and cell-specific transcriptomic insights into MRI-derived cortical morphology in macaque monkeys.Nature communications · 2023Article
- Gene co-expression analyses of health(span) across multiple species.NAR genomics and bioinformatics · 2022Article
- Single-cell analysis reveals transcriptomic reprogramming in aging primate entorhinal cortex and the relevance with Alzheimer's disease.Aging cell · 2022Article
- Multi-omics analysis reveals the host-microbe interactions in aged rhesus macaques.Frontiers in microbiology · 2022Article
- Alternative splicing in normal and pathological human placentas is correlated to genetic variants.Human genetics · 2021Article
- Deficits in motor and cognitive functions in an adult mouse model of hypoxia-ischemia induced stroke.Scientific reports · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundBrain aging is a complex process that depends on the precise regulation of multiple brain regions; however, the underlying molecular mechanisms behind this process remain to be clarified in non-human primates.
resultsHere, we explore non-human primate brain aging using 547 transcriptomes originating from 44 brain areas in rhesus macaques (Macaca mulatta). We show that expression connectivity between pairs of cerebral cortex areas as well as expression symmetry between the left and right hemispheres both decrease after aging. Although the aging mechanisms across different brain areas are largely convergent, changes in gene expression and alternative splicing vary at diverse genes, reinforcing the complex multifactorial basis of aging. Through gene co-expression network analysis, we identify nine modules that exhibit gain of connectivity in the aged brain and uncovered a hub gene, PGLS, underlying brain aging. We further confirm the functional significance of PGLS in mice at the gene transcription, molecular, and behavioral levels.
conclusionsTaken together, our study provides comprehensive transcriptomes on multiple brain regions in non-human primates and provides novel insights into the molecular mechanism of healthy brain aging.
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