Evidence map›Paper›PMID 31779655›Full record

ArticleBreast cancer research : BCR2019

Alcohol consumption, cigarette smoking, and familial breast cancer risk: findings from the Prospective Family Study Cohort (ProF-SC).

Nur Zeinomar, Julia A Knight, Jeanine M Genkinger, Kelly-Anne Phillips, Mary B Daly, Roger L Milne, Gillian S Dite, Rebecca D Kehm, Yuyan Liao, Melissa C Southey and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Breast cancer research : BCR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 5 pooled it
2.1field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 5 syntheses or guidelines pooled it, 54 citations in OpenAlex.

  1. Pooled it
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  3. Risk factors for breast cancer in women: an update review.Medical oncology (Northwood, London, England) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 3 countries.

Nur ZeinomarDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th Street, Room 1611, New York, NY, 10032, USA.
Julia A KnightLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Jeanine M GenkingerDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th Street, Room 1611, New York, NY, 10032, USA.
Kelly-Anne PhillipsCentre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
Mary B DalyDepartment of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA, USA.
Roger L MilneCentre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
Gillian S DiteCentre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
Rebecca D KehmDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th Street, Room 1611, New York, NY, 10032, USA.
Yuyan LiaoDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th Street, Room 1611, New York, NY, 10032, USA.
Melissa C SoutheyCancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Wendy K ChungHerbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, USA.
Graham G GilesCentre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
Sue-Anne McLachlanDepartment of Medicine, St Vincent's Hospital, The University of Melbourne, Parkville, Victoria, Australia.
Michael L FriedlanderPrince of Wales Clinical School, University of New South Wales, Sydney, New South Wales, Australia.
Prue C WeidemanCentre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
Gord GlendonLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Stephanie NesciDepartment of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
kConFab Investigators
Irene L AndrulisLunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, Ontario, Canada.
Saundra S BuysDepartment of Medicine and Huntsman Cancer Institute, University of Utah Health Sciences Center, Salt Lake City, UT, USA.
Esther M JohnDepartment of Medicine and Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
Robert J MacInnisCentre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
John L HopperCentre for Epidemiology and Biostatistics, The University of Melbourne, Parkville, Victoria, Australia.
Mary Beth TerryDepartment of Epidemiology, Mailman School of Public Health, Columbia University, 722 W. 168th Street, Room 1611, New York, NY, 10032, USA. mt146@cumc.columbia.edu.ORCID 0000-0002-4106-5033
The University of Melbourne · AULunenfeld-Tanenbaum Research Institute · CACancer Council Victoria · AUColumbia University · USFox Chase Cancer Center · USUniversity of Toronto · CAColumbia University Irving Medical Center · USUniversity of Utah · US

Funding

True Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7M
Breast Cancer Family Registry CohortUM1CA164920 · NCI · CANCER PREVENTION INSTIT OF CALIFORNIA · PI ANDRULIS, IRENE, BUYS, SAUNDRA S · 2012 to 2017
$12.7M
Genes, environment and breast cancer risk: The 15 year follow-up of the Prof-SC (Diversity Supplement)R01CA159868 · NCI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI HOPPER, JOHN L, TERRY, MARY BETH · 2011 to 2015
$9.0M
NRSA Training CoreTL1TR001875 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SPANN, MARISA N, TAYLOR, JACQUELYN Y · 2016 to 2025
$8.9M
CANCER EPIDEMIOLOGY/BIOSTATISTICS/ENVIRONMENTAL SCIENCEST32CA009529 · NCI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI NEUGUT, ALFRED I. · 1985 to 2012
$4.3M
NCATS NIH HHS TL1 TR001875NCI NIH HHS R01 CA159868NCI NIH HHS T32 CA009529NCI NIH HHS UM1 CA164920NIEHS NIH HHS P30 ES009089
6 · The paper itself

Abstract

backgroundAlcohol consumption and cigarette smoking are associated with an increased risk of breast cancer (BC), but it is unclear whether these associations vary by a woman's familial BC risk.

methodsUsing the Prospective Family Study Cohort, we evaluated associations between alcohol consumption, cigarette smoking, and BC risk. We used multivariable Cox proportional hazard models to estimate hazard ratios (HR) and 95% confidence intervals (CI). We examined whether associations were modified by familial risk profile (FRP), defined as the 1-year incidence of BC predicted by Breast Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA), a pedigree-based algorithm.

resultsWe observed 1009 incident BC cases in 17,435 women during a median follow-up of 10.4 years. We found no overall association of smoking or alcohol consumption with BC risk (current smokers compared with never smokers HR 1.02, 95% CI 0.85-1.23; consuming ≥ 7 drinks/week compared with non-regular drinkers HR 1.10, 95% CI 0.92-1.32), but we did observe differences in associations based on FRP and by estrogen receptor (ER) status. Women with lower FRP had an increased risk of ER-positive BC associated with consuming ≥ 7 drinks/week (compared to non-regular drinkers), whereas there was no association for women with higher FRP. For example, women at the 10th percentile of FRP (5-year BOADICEA = 0.15%) had an estimated HR of 1.46 (95% CI 1.07-1.99), whereas there was no association for women at the 90th percentile (5-year BOADICEA = 4.2%) (HR 1.07, 95% CI 0.80-1.44). While the associations with smoking were not modified by FRP, we observed a positive multiplicative interaction by FRP (p

conclusionsModerate alcohol intake was associated with increased BC risk, particularly for women with ER-positive BC, but only for those at lower predicted familial BC risk (5-year BOADICEA < 1.25). For women with a high FRP (5-year BOADICEA ≥ 6.5%) who also consumed alcohol, being a current smoker was associated with increased BC risk.

Indexed as

AdolescentAdultAgedAlcohol DrinkingBreast NeoplasmsCigarette SmokingDisease SusceptibilityFemaleHumansMiddle AgedProportional Hazards ModelsProspective StudiesPublic Health SurveillanceRisk AssessmentRisk FactorsSurveys and QuestionnairesAlcohol consumptionBOADICEABreast cancerCigarette smokingFamilial risk

Identifiers

PMID31779655
PMCPMC6883541
OpenAlexW2990891023

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.