Evidence map›Paper›PMID 31779124›Full record

ArticleMolecules (Basel, Switzerland)2019

Lipophilicity Determination of Antifungal Isoxazolo[3,4-

Krzesimir Ciura, Joanna Fedorowicz, Filip Andrić, Petar Žuvela, Katarzyna Ewa Greber, Paweł Baranowski, Piotr Kawczak, Joanna Nowakowska, Tomasz Bączek, Jarosław Sączewski

Abstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Affinity of Antifungal Isoxazolo[3,4-Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Krzesimir CiuraDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Joanna FedorowiczDepartment of Chemical Technology of Drugs, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0001-7524-9909
Filip AndrićDepartment of Analytical Chemistry, University of Belgrade-Faculty of Chemistry, Studentski trg 12-16, 11000 Belgrade, Serbia.ORCID 0000-0001-7932-833X
Petar ŽuvelaDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0001-6481-2241
Katarzyna Ewa GreberDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Paweł BaranowskiDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Piotr KawczakDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0003-3902-2744
Joanna NowakowskaDepartment of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.
Tomasz BączekDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Gdansk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0001-6468-1974
Jarosław SączewskiDepartment of Organic Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland.ORCID 0000-0003-2966-7645

Funding

the Polish Ministry of Science and Higher Education research grant number 01-0471/08/518
6 · The paper itself

Abstract

The lipophilicity of a molecule is a well-recognized as a crucial physicochemical factor that conditions the biological activity of a drug candidate. This study was aimed to evaluate the lipophilicity of isoxazolo[3,4-

Indexed as

Antifungal AgentsChromatography, High Pressure LiquidChromatography, Reverse-PhaseChromatography, Thin LayerHydrophobic and Hydrophilic InteractionsLipidsPrincipal Component AnalysisPyridinesQuantitative Structure-Activity RelationshipAntifungal AgentsLipidspyridinePyridinesisoxazolo[3,4-b]pyridin-3(1H)-oneisoxazolonelipophilicityQSRR analysisreversed-phase liquid chromatographysum of ranking differences

Identifiers

PMID31779124
PMCPMC6930598

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.