Evidence map›Paper›PMID 31778800›Full record

ReviewParasitology international2020

The immune system utilizes two distinct effector mechanisms of T cells depending on two different life cycle stages of a single pathogen, Toxoplasma gondii, to control its cerebral infection.

Yasuhiro Suzuki

Open access · greenAbstract readReview
In one paragraph

Review in Parasitology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Effects of diet and ovariectomy onBrain communications · 2025
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  3. Infection and immunity · 2024
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  5. Therapeutic potential ofBrain communications · 2024
    Article
  6. The emerging role ofFrontiers in immunology · 2024
    Review
  7. Review
  8. Review
  9. Variation in CD8 T cell IFNγ differentiation to strains ofFrontiers in cellular and infection microbiology · 2023
    Article
  10. From the immune system to mood disorders especially induced byFrontiers in cellular and infection microbiology · 2023
    Review
  11. Article
  12. Article
  13. Forward Genetics in Apicomplexa Biology: The Host Side of the Story.Frontiers in cellular and infection microbiology · 2022
    Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Key Limitations and New Insights Into theFrontiers in cellular and infection microbiology · 2020
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Yasuhiro SuzukiDepartment of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, KY, USA. Electronic address: yasu.suzuki@uky.edu.
University of Kentucky · US

Funding

Cooperation of CD8+ T cells and phagocytes to eliminate Toxoplasma cystsR01AI095032 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2012 to 2023
$4.1M
IFN-gamma production by microglia for prevention of toxoplasmic encephalitisR01AI078756 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SUZUKI, YASUHIRO · 2008 to 2012
$1.8M
Effector molecules for IFN-gamma-mediated prevention of Toxoplasma proliferation in the brainR21AI134323 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2017 to 2018
$421k
Gender-dependent innate IL-10 production as a key pathogenic factor to promote toxoplasmic encephalitisR21AI136821 · NIAID · UNIVERSITY OF KENTUCKY · PI SUZUKI, YASUHIRO · 2018 to 2019
$421k
Elimination of Toxoplasma gondii cysts by T cellsR21AI073576 · NIAID · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI SUZUKI, YASUHIRO · 2008 to 2009
$412k
NIAID NIH HHS R01 AI078756NIAID NIH HHS R01 AI095032NIAID NIH HHS R21 AI073576NIAID NIH HHS R21 AI134323NIAID NIH HHS R21 AI136821
6 · The paper itself

Abstract

Toxoplasma gondii takes two different life cycle stages within intermediate hosts including humans. Tachyzoites proliferate during the acute stage, and they transform into cysts to establish a chronic infection preferentially in the brain. IFN-γ production by infiltrated CD4

Indexed as

AnimalsBrainCD8-Positive T-LymphocytesChemokinesHumansImmunity, CellularInterferon-gammaLife Cycle StagesMicePerforinToxoplasmaToxoplasmosis, CerebralChemokinesInterferon-gammaPerforinCystsIFN-γPerforinTachyzoiteT cell invasionToxoplasma

Identifiers

PMID31778800
PMCPMC7136146
OpenAlexW2990579530

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.